阿托伐他汀钙联合高压氧治疗颅脑损伤术后硬膜下积液的效果分析  

Analysis of the effects of atorvastatin calcium combined with hyperbaric oxygen therapy on postoperative subdural effusion following cranial injury

作　　者：杨金理 欧小晶 申隆 黄开让 YANG Jinli;OU Xiaojing;SHEN Long(The Second Department of Neurosurgery,Yangjiang People's Hospital,Yangjiang 529500,China;不详)

机构地区：[1]阳江市人民医院神经外二科,广东阳江529500 [2]阳江市人民医院神经内一科,广东阳江529500

出　　处：《中国处方药》2024年第12期108-111,共4页Journal of China Prescription Drug

摘　　要：目的分析阿托伐他汀钙联合高压氧治疗颅脑损伤术后硬膜下积液的效果。方法选择2020年1月~2024年4月收治的颅脑损伤术后硬膜下积液80例患者,通过摸球法分组,奇数为对照组(40例),偶数为试验组(40例)。对照组接受高压氧治疗,试验组接受阿托伐他汀钙联合高压氧治疗。对比两组临床疗效、炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]、血浆脑损伤标志物水平[血浆人S100B蛋白(S-100B)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)]、硬膜下积液量、颅内压恢复状况、神经功能缺损程度评定量表(CSS)评分、美国国立卫生研究院卒中评分(NIHSS)的差异。结果试验组治疗总有效率为97.50%,高于对照组的77.50%,差异有统计学意义(χ^(2)=7.314,P<0.05);治疗30 d后,试验组hs-CRP、IL-1β和TNF-α水平低于对照组(P<0.05)。试验组S-100B、NSE、MBP水平低于对照组,差异有统计学意义(P<0.05);试验组的颅内压恢复速度快于对照组,治疗后,试验组硬膜下积液量(5.17±1.02)ml,CSS评分、NIHSS评分为(13.14±3.54)分、(20.54±2.13)分,低于对照组(6.33±1.20)ml、(18.47±4.17)分、(23.48±2.60)分,差异均有统计学意义(P<0.05)。结论阿托伐他汀钙联合高压氧治疗颅脑损伤术后硬膜下积液患者,可改善硬膜下积液处理效果,加速颅内压恢复,有效降低炎症因子和脑损伤标志物水平,促进神经功能恢复。Objective To evaluate the effects of atorvastatin calcium combined with hyperbaric oxygen therapy on postoperative subdural effusion in patients with cranial injuries.Methods From January 2020 to April 2024,a total of 80 patients with postoperative subdural effusion were included in a study.Patients were grouped by a balloting method;odd numbers formed the control group(40 patients)receiving hyperbaric oxygen therapy,and even numbers formed the experimental group(40 patients)receiving both atorvastatin calcium and hyperbaric oxygen therapy.The two groups were compared in terms of treatment efficacy,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)],plasma brain injury biomarkers[human S100B protein(S-100B),neuron-specific enolase(NSE),myelin basic protein(MBP)],volume of subdural effusion,intracranial pressure recovery,CSS scores,and NIHSS scores.Results The total effective rate in the experimental group was 97.50%,significantly higher than 77.50%in the control group,with a statistically significant difference(χ^(2)=7.314,P<0.05).After 30 days of treatment,the levels of hs-CRP,IL-1β,and TNF-αin the experimental group were lower than those in the control group,with significant differences(P<0.05).The levels of S-100B,NSE,and MBP in the experimental group were lower than those in the control group(P<0.05).The intracranial pressure recovery time in the experimental group faster than those in the control group.Post-treatment,the subdural collection of fluid,CSS and NIHSS scores in the experimental group were(5.17±1.02)ml,(13.14±3.54)and(20.54±2.13)respectively,lower than(6.33±1.20)ml,(18.47±4.17)and(23.48±2.60)in the control group,with significant differences(P<0.05).Conclusion Atorvastatin calcium combined with hyperbaric oxygen therapy in patients with postoperative subdural effusion following cranial injury not only improves the treatment of subdural effusion and accelerates the recovery of intracranial pressure but also effectively r

关 键 词：阿托伐他汀钙 高压氧治疗 颅脑损伤 硬膜下积液 脑损伤标志物 

分 类 号：R651.15[医药卫生—外科学]