低剂量重组人干扰素α2a联合奥司他韦治疗小儿病毒性肺炎的临床效果及药理作用分析  

Pharmacological role and clinical effect of low-dose recombinant human interferonα2a combined with oseltamivir in the treatment of viral pneumonia in children

作　　者：陈玉芬 丘美红 CHEN Yufen;QIU Meihong(Department of Pharmacy,Wengyuan Maternal and Child Health Care Hospital,Shaoguan 512600,China)

机构地区：[1]翁源县妇幼保健院药剂科,广东韶关512600

出　　处：《中国处方药》2024年第12期151-155,共5页Journal of China Prescription Drug

摘　　要：目的探讨低剂量重组人干扰素α2a(rhIFNα2a)联合奥司他韦治疗小儿病毒性肺炎的效果。方法遴选小儿病毒性肺炎99例为观察对象,随机分为对照组(奥司他韦治疗)、低剂量组(20μg/d rhIFNα2a+奥司他韦)、高剂量组(40μg/d rhIFNα2a+奥司他韦)各33例,对比三组治疗7 d的临床疗效、相关指标和治疗前及治疗7 d后的血清免疫球蛋白、炎症因子和氧化损伤指标水平。结果低、高剂量组治疗总有效率(84.85%、87.88%)均显著高于对照组(60.61%)(P<0.05),但三组间、低剂量组与高剂量组间的上述指标差异均无统计学意义(P>0.05),低、高剂量组症状(发热及咳嗽)缓解时间以及住院时间、平均病程显著短于对照组(P<0.05),低、高剂量组间比较,差异无统计学意义(P>0.05);三组治疗7 d后血清IgM、IgG含量和SP-D、TLR2及MDA水平显著低于治疗前(P<0.05),血清SOD水平显著高于治疗前(P<0.05),低、高剂量组变化幅度显著大于对照组(P<0.05),低、高剂量组对比差异无统计学意义(P>0.05)。结论低、高剂量rhIFNα2a分别联合奥司他韦治疗小儿病毒性肺炎疗效一致,均优于单一奥司他韦治疗,均能改善其病情,提高患儿的免疫功能,且能明显减轻其炎症反应和脂质过氧化损伤程度,但低剂量重组人干扰素α2a的不良反应更少。Objective To investigate the pharmacological role and clinical effect of low-dose recombinant human interferonα2a(rhIFNα2a)combined with oseltamivir in the treatment of viral pneumonia in children.Methods 99 children with viral pneumonia were selected as the observation objects,and randomized into the control group(to be treated with oseltamivir),low-dose group(to be treated with 20μg/d rhIFNα2a and oseltamivir)and high-dose group(to be treated with 40μg/d rhIFNα2a and oseltamivir),with 33 cases in each group.The control group was treated with oseltamivir orally,low-dose group was given 20μg/d recombinant human interferonα2a combined with oseltamivir,and high-dose group received 40μg/d recombinant human interferonα2a combined with oseltamivir.The clinical efficacy and related indicators after 7 days of treatment and levels of serum immunoglobulins,inflammatory factors and oxidative damage indexes before treatment and after 7 days of treatment were compared among the three groups.Results The total effective rate in low-dose(84.85%)and high-dose groups(87.88%)was significantly higher than that in the control group(60.61%)(P<0.05).The fever time,cough time,hospitalization time and average course of disease in low-dose and high-dose groups were significantly shorter than those in the control group(P<0.05),but there were no statistical differences in the above indexes among the three groups and between low-dose group and high-dose group(P>0.05).The remission time of symptoms(fever and cough),hospitalization time and average course of disease in the low and high dose groups were sighificantly shorter than those in the control group(P<0.05).There was no significant difference between the low and high dose groups(P>0.05).The levels of serum IgM and IgG and serum SP-D,TLR2 and MDA in the three groups after 7 days of treatment were significantly lower than those before treatment(P<0.05)while the level of serum SOD was significantly higher(P<0.05),and the changes in low-dose and high-dose groups were significantly

关 键 词：小儿病毒性肺炎 重组人干扰素Α2A 低剂量 奥司他韦 炎症反应 脂质过氧化损伤 

分 类 号：R725.6[医药卫生—儿科]