不同性别痤疮患者皮肤生理屏障功能的比较以及与痤疮严重程度的相关性分析  

Comparison of skin physiological barrier function and its correlation with severity of acne in patients of different genders

作　　者：王琪 范莹 陶诗沁 Wang Qi;Fan Ying;Tao Shiqin(Department of Dermatology,Wuxi No 2 People's Hospital,Jiangnan University Medical Center,Wuxi 214000,China)

机构地区：[1]江南大学附属中心医院无锡市第二人民医院皮肤科,无锡214000

出　　处：《中华医学美学美容杂志》2024年第6期547-550,共4页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：江苏省无锡市医管中心面上项目(YGZXM1511)。

摘　　要：目的比较不同性别痤疮患者皮肤生理屏障功能的差异,探讨其与痤疮严重程度的相关性。方法前瞻性纳入2021年4月至2022年12月无锡市第二人民医院皮肤科寻常痤疮患者236例,男84例,女152例,中位年龄26(12~45)岁;另纳入同期本院非皮肤病健康对照者62名,男30名,女32名,中位年龄27(13~45)岁。采用CK皮肤检测仪及VISIA皮肤图像分析仪检测健康对照组和痤疮患者组皮肤生理屏障参数,包括经表皮失水量(TEWL)、皮肤含水量、pH值、红斑指数和黑色素指数。使用全球痤疮分级系统(GAGS)评分评估痤疮的严重程度。比较男性和女性痤疮患者上述皮肤生理屏障参数的差异,并探讨其与痤疮严重程度的相关性。结果与女性痤疮组相比,男性痤疮组的GAGS评分更高,TEWL值更高,皮肤含水量更低,红斑指数和黑色素指数更高,差异均有统计学意义(均P<0.05)。女性痤疮患者的TEWL值和粉刺数量(r=0.14,P=0.045)以及GAGS评分(r=0.15,P=0.036)呈弱正相关;TEWL值和皮肤含水量呈弱负相关(r=-0.24,P=0.002)。男性痤疮患者的年龄与pH值呈中等强度正相关(r=0.45,P=0.003);红斑指数与结节性囊肿数量(r=0.34,P=0.002)以及黑色素指数(r=0.35,P=0.018)呈弱正相关;TEWL值与皮肤含水量呈中等强度负相关(r=-0.44,P=0.003)。结论与女性痤疮患者相比,男性患者的皮肤生理屏障功能更差。女性患者的皮肤生理屏障功能越差,痤疮越严重;男性患者的皮肤生理屏障功能与痤疮的严重程度无相关性。ObjectiveTo compare the skin biophysical properties in acne patients of different gender and to further explore their association with skin biophysical properties.MethodsA total of 236 patients with acne vulgaris from the Department of Dermatology,Wuxi Second People's Hospital from April 2021 to December 2022 were prospectively enrolled,including 84 males and 152 females,with a median age of 26(12-45)years.In addition,62 healthy controls without skin diseases were included in this hospital during the same period,including 30 males and 32 females,with a median age of 27(13-45)years.CK skin detector and VISIA skin image analyzer were used to detect physiological barrier parameters of the skin in the healthy control group and acne patient group,including transepidermal water loss(TEWL),skin hydration,pH value,erythema index,and melanin index.Global Acne Grading System(GAGS)score was used to assess the severity of acne.The aim was to compare the differences in the above skin physiological barrier parameters between male and female acne patients,and to explore their correlation with the severity of acne.ResultsCompared with the female acne group,the male acne group had higher GAGS score,higher TEWL value,lower skin hydration,higher erythema index and melanin index,and the differences were statistically significant(all P<0.05).There was a weak positive correlation between the TEWL value and the number of comedones(r=0.14,P=0.045)as well as the GAGS score(r=0.15,P=0.036)in female acne patients;The TEWL value was weakly negatively correlated with skin hydration(r=-0.24,P=0.002).The age of male acne patients was moderately positively correlated with pH value(r=0.45,P=0.003).The erythema index was weakly positively correlated with the number of nodular cysts(r=0.34,P=0.002)and the melanin index(r=0.35,P=0.018);The TEWL value was moderately negatively correlated with skin hydration(r=-0.44,P=0.003).ConclusionsCompared with female acne patients,male patients have poorer skin physiological barrier function.The worse the physi

关 键 词：寻常痤疮 经表皮失水量 皮肤含水量 年龄 红斑指数 黑素指数 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]