血清NF-κB、TIMP-1、IL-8与儿童幽门螺杆菌感染相关性胃炎的关系  

Study on the correlation of serum NF-κB, TIMP-1, and IL-8 with Helicobacter pylori-associated gastritis in pediatric patients

作　　者：宋鹏[1] 白青山[1] SONG Peng;BAI Qingshan(Department of Pediatric Gastroenterology,Tangshan Maternal and Children Health Hospital,Hebei,Tangshan 063000,China)

机构地区：[1]河北省唐山市妇幼保健院小儿消化科,063000

出　　处：《河北医药》2024年第24期3781-3783,3787,共4页Hebei Medical Journal

基　　金：河北省医学科学研究课题(编号:20201487)。

摘　　要：目的分析血清核因子-κB(NF-κB)、基质金属蛋白酶抑制因子-1(TIMP-1)、白细胞介素-8(IL-8)与儿童幽门螺杆菌(H.pylori)感染相关性胃炎的关系。方法选取2021年7月至2023年7月就诊的60例H.pylori感染相关性胃炎患儿设为观察组,另选取同期体检中心的60例健康体检儿童设为健康组,检测、比较2组血清NF-κB、TIMP-1、IL-8水平,比较观察组患者不同炎性活动度组血清NF-κB、TIMP-1、IL-8水平,比较观察组患者治疗前后血清NF-κB、TIMP-1、IL-8水平,绘制受试者工作曲线(ROC),分析血清NF-κB、TIMP-1、IL-8对H.pylori感染相关性胃炎的诊断效能。结果观察组血清NF-κB、TIMP-1、IL-8水平均高于健康组(P<0.05)。重度组血清NF-κB、TIMP-1、IL-8水平均高于中度组、轻度组(P<0.05),中度组血清NF-κB、TIMP-1、IL-8水平均高于轻度组(P<0.05)。治疗后血清NF-κB、TIMP-1、IL-8水平低于治疗前(P<0.05)。血清NF-κB、TIMP-1、IL-8联合检测诊断H.pylori感染相关性胃炎的AUC是0.904,95%CI可信区间是0.856~0.951,联合检测的灵敏度(94.82%)、特异度(90.13%)均高于单一检测(73.82%、71.62%)、(72.26%、68.18%)、(70.18%、64.74%),差异有统计学意义(P<0.05)。结论H.pylori感染相关性胃炎患儿血清NF-κB、TIMP-1、IL-8呈异常高表达,血清NF-κB、TIMP-1、IL-8表达量与炎性活动度及疗效存在密切联系,联合检测可提高对H.pylori感染相关性胃炎的诊断效能,值得借鉴。Objective To analyze the correlation of serum nuclear factor-κB(NF-κB),matrix metalloproteinase-1(TIMP-1),and interleukin-8(IL-8)with Helicobacter pylori(HP)-associated gastritis in pediatric patients.Methods A total of 60 children with HP-associated gastritis treated in our hospital from July 2021 to July 2023 were selected as the observation group,and another 60 healthy children from the physical examination center of our hospital during the same period were selected as the healthy group.Serum NF-κB,TIMP-1 and IL-8 levels were detected and compared between the two groups.Their levels in children of the observation group with varying inflammatory activities were compared before and after treatment.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of serum NF-κB,TIMP-1 and IL-8 HP-associated gastritis in pediatric patients.Results Serum levels of NF-κB,TIMP-1 and IL-8 in the observation group were significantly higher than those of the healthy group(P<0.05).Serum NF-κB,TIMP-1 and IL-8 levels in severe group were significantly higher than those of moderate group and mild group(P<0.05).Serum NF-κB,TIMP-1 and IL-8 levels in moderate group were significantly higher than those of mild group(P<0.05).Serum levels of NF-κB,TIMP-1 and IL-8 after treatment were significantly lower than those before treatment(P<0.05).The area under the curve(AUC)of the combined detection of serum NF-κB,TIMP-1 and IL-8 in the diagnosis of H.pylori-associated gastritis in pediatric patients was 0.904,and the 95%confidence interval(CI)was 0.856 to 0.951.The sensitivity(94.82%)and specificity(90.13%)of combined detection were significantly higher than those of a single detection([73.82%,71.62%];[72.26%,68.18%];[70.18%,64.74%],P<0.05).Conclusion Serum NF-κB,TIMP-1 and IL-8 are abnormally high in children with HP infection-associated gastritis.Their levels are closely related to inflammatory activity and therapeutic effect.A combined detection can improve the diagnostic efficiency of H.pylori-a

关 键 词：核因子-ΚB 基质金属蛋白酶抑制因子-1 白细胞介素-8 儿童 幽门螺杆菌 胃炎 

分 类 号：R725.733[医药卫生—儿科]