尪痹制剂治疗类风湿关节炎的研究进展  

Research progress of Wang-bi preparations in the treatment of rheumatoid arthritis

作　　者：尹谢添 赵诗超 卢绮萍 朱晓密 徐俊 谭张奎 YIN Xietian;ZHAO Shichao;LU Qiping(General Hospital of Central Theater Command,Hubei,Wuhan 430061,China)

机构地区：[1]中国人民解放军中部战区总医院,武汉市430061 [2]湖北中医药大学附属湖北省中医院

出　　处：《河北医药》2024年第24期3806-3811,共6页Hebei Medical Journal

基　　金：湖北省自然科学基金(编号:2023AFD136);中国人民解放军中部战区总医院博士后科研启动基金(编号:20230919KY42)。

摘　　要：类风湿关节炎(RA)是一种病因不明的自身免疫病,病情呈进展性,具有发病率高和致残率高的特点,容易给患者造成巨大的身心痛苦和经济负担。RA发病机制至今尚不明确,西药虽能有效控制病情进展,但多不良反应较大,并存在增加继发感染、消化道疾病的风险。尪痹制剂包括尪痹胶囊和尪痹片等,是以焦树德创立的补肾祛寒治尪汤为主加减制成的中成药,有补肾强骨、祛风除湿、通络止痛之功效,现已广泛应用于临床。近年来,现代临床及药理学研究表明槲皮素、木犀草素、山奈酚、豆甾醇等为尪痹制剂中的有效成分,能抗炎止痛、调节免疫、抑制骨破坏,进而有效治疗RA,有较为广泛的应用前景。本研究探讨RA的中西医病因病机,从化学成分、临床研究、基础研究等角度综述尪痹制剂治疗RA的研究进展,明确其治疗RA的有效性与安全性,为其应用前景提供一定理论依据,为中医药广泛应用于RA临床提供更深入的思考。Rheumatoid arthritis(RA)is an autoimmune disease of unknown etiology,with a progressive condition,high incidence and high disability rate.It easily causes huge physical,mental pain and economic burden to patients.The pathogenesis of RA is still unclear.Although Western medicine can control the progression of RA,it causes adverse events and increases the risk of secondary infections and gastrointestinal diseases.Wang-bi preparations include Wang-bi capsules and Wang-bi tablets,which is a Chinese patent medicine made by Jiao Shu-de.It is functional of tonifying kidney and strengthening bone,eliminating wind and removing dampness,and activating meridians to stop pain,which has been widely used in clinic.In recent years,modern clinical and pharmacological studies have shown that quercetin,luteolin,kaempferol and stigmasterol are the active components in Wang-bi preparations,which can effectively treat RA with the properties of anti-inflammatory and analgesic activities,immune regulation,and inhibition of bone destruction,presenting a wide application prospect.This study discussed the etiology and pathogenesis of RA and reviewed the research progress of Wang-bi preparations in the treatment of RA from the aspects of chemical composition,clinical research and basic research.We also clarified its effectiveness and safety.Our article provided a certain theoretical basis for its application prospects,and a deeper thinking for the widespread application of traditional Chinese medicine in the clinic of RA.

关 键 词：尪痹胶囊 尪痹片 类风湿关节炎 作用机制 研究进展 

分 类 号：R593.22[医药卫生—内科学]