妊娠期高血压疾病血清25-(OH)D FABP4 sVEGFR-1水平变化及与病情进展的关系探究  

Correlation between Serum 25OHD FABP4 and sVEGFR-1 with Disease Progression in Hypertensive Disorder of Pregnancy

作　　者：孟晓辉[1] 于媛媛 黄睿[1] MENG Xiaohui;YU Yuanyuan;HUANG Rui(Xinjiang Uygur Municipal People's Hospital,Xinjiang Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001

出　　处：《河北医学》2024年第12期2064-2068,共5页Hebei Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目,(编号:2023D01C59)。

摘　　要：目的:探究妊娠期高血压疾病(HDP)患者血清25羟维生素D[25-(OH)D]、脂肪酸结合蛋白4(FABP4)、可溶性血管内皮生长因子受体-1(sVEGFR-1)水平变化及与病情进展的关系。方法:选取2022年10月至2023年10月新疆维吾尔自治区人民医院HDP患者120例作为研究组,120例正常孕妇作为对照组。将研究组患者根据病情进展情况分为妊娠期高血压(GH)亚组(79例)和子痫前期(PE)亚组(41例)。比较研究组、对照组入院时血清25-(OH)D、FABP4、sVEGFR-1水平,并比较两亚组入院时血清25-(OH)D、FABP4、sVEGFR-1水平及不良妊娠结局发生情况,分析入院时血清25-(OH)D、FABP4、sVEGFR-1水平与GH进展至PE的关系,比较不同妊娠结局患者入院时血清25-(OH)D、FABP4、sVEGFR-1水平,分析各指标评估GH进展至PE的价值及预测不良妊娠结局的价值。结果:研究组入院时血清25-(OH)D水平低于对照组,FABP4、sVEGFR-1水平高于对照组,差异具有统计学意义(P<0.05);PE亚组入院时血清25-(OH)D水平及不良妊娠结局发生率低于GH亚组,FABP4、sVEGFR-1水平高于GH亚组,差异具有统计学意义(P<0.05);入院时低血清25-(OH)D水平和高血清FABP4、sVEGFR-1水平均为GH进展至PE的独立危险因素(P<0.05);研究组不良妊娠结局总发生率为35.83%(43/120),不良妊娠结局患者入院时血清25-(OH)D水平低于妊娠结局良好患者,FABP4、sVEGFR-1水平高于妊娠结局良好患者,差异具有统计学意义(P<0.05);入院时血清25-(OH)D、FABP4、sVEGFR-1评估GH进展至PE的曲线下面积(AUC)分别为0.793、0.813、0.835,各指标联合评估的AUC为0.937,大于单独评估的AUC,差异具有统计学意义(P<0.05);入院时血清25-(OH)D、FABP4、sVEGFR-1预测HDP患者不良妊娠结局的AUC分别为0.810、0.757、0.772,各指标联合评估的AUC为0.930,大于单独评估的AUC,差异具有统计学意义(P<0.05)。结论:HDP患者血清25-(OH)D水平降低,血清FABP4、sVEGFR-1水平升高,且是GH进展至PE的独�Objective:To investigate correlation between serum levels of 25-hydroxyvitamin D(25OHD),fatty acid binding protein 4(FABP4),and soluble vascular endothelial growth factor receptor-1(sVEGFR-1)with disease progression of pregnant women with hypertensive disorders of pregnancy(HDP).Methods:From October 2022 to October 2023,120 pregnant women with HDP in People's Hospital of Xinjiang Uygur Autonomous Region(study group)and 120 normal pregnant women(control group)were included.The patients in the study group were assigned into the gestational hypertension(GH)subgroup(n=79)and the pre-eclampsia(PE)subgroup(n=41)according to the disease progression.At admission,the levels of serum 25OHD,FABP4,and sVEGFR-1 were compared between the study group and the control group,and the levels of serum 25OHD,FABP4,and sVEGFR-1 and the incidence of adverse pregnancy outcome were compared between the two subgroups.The correlation between the levels of serum 25OHD,FABP4,and sVEGFR-1 at admission with the progression of GH to PE was assessed.The levels of serum 25OHD,FABP4,and sVEGFR-1 at admission were compared among patients with different pregnancy outcomes,and the values of the indexes in evaluating the progression of GH to PE and predicting adverse pregnancy outcomes were analyzed.Results:At admission,the study group had significantly lower serum 25OHD level,and higher levels of FABP4 and sVEGFR-1 than the control group(all P<0.05).PE subgroup had significantly lower serum 25OHD level and the incidence of adverse pregnancy outcomes,and higher levels of FABP4 and sVEGFR-1 than the GH subgroup(all P<0.05).Low serum 25OHD levels and high serum FABP4 and sVEGFR-1 levels at admission were independent risk factors for the progression of GH to PE(P<0.05).The total incidence of adverse pregnancy outcomes in the study group was 35.83%(43/120).At admission,the patients with poor pregnancy outcomes presented significantly lower serum 25OHD level,and higher levels of FABP4 and sVEGFR-1 than those with good pregnancy outcomes(P<0.05);the area und

关 键 词：妊娠期高血压 子痫前期 25羟维生素D 脂肪酸结合蛋白4 可溶性血管内皮生长因子受体-1 

分 类 号：R714.246[医药卫生—妇产科学]