2型糖尿病视网膜病变患者血清中Asprosin水平变化  

To Investigate the Changes of Serum Asprosin Levels in Diabetic Retinopathy Patients at Different Stages

作　　者：韩晶 蔺晓慧 HAN Jing;LIN Xiaohui(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040 China;Inner Mongolia Autonomous Region People's Hospital,Hohhot 010017 China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古自治区人民医医院,呼和浩特010017

出　　处：《内蒙古医学杂志》2024年第11期1315-1322,共8页Inner Mongolia Medical Journal

摘　　要：目的测定糖尿病视网膜病变(diabetic retinopathy,DR)患者血清中脂肪因子白脂素(Asprosin)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)及血管内皮生长因子(vascular endothelial growth factor,VEGF)水平,分析4种因子与DR及氧化应激的相关性。方法将2022年11月至2023年10月在内蒙古自治区人民医院眼科住院的2型糖尿病(type 2 diabetes mellitus,T2DM)患者139例纳入研究。将患者结合DR分期标准分为3组:增殖期糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)组39例,非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)组47例,糖尿病无视网膜病变(non-diabetic retinopathy,NDR)组53例,单纯白内障患者61例为对照组(NC组)。采用酶联免疫吸附法测定各组血清中Asprosin、SOD、MDA及VEGF水平,同时,收集患者性别、年龄、体质量、身高、BMI、糖尿病病程、空腹血糖(fasting plasma glucose,FPG)、空腹C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FIN)、低密度脂蛋白(low-density lipoprotein cholesterol,LDL-C)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白(high-density lipoprotein cholesterol,HDL-C)等指标,计算胰岛素抵抗指数(homeostatic model assessment of insulin resistance,HOMA-IR),将以上数据进行统计学分析。结果PDR组血清Asprosin、MDA及VEGF水平高于NPDR组及NDR组,且均高于NC组,两两组间差异具有统计学意义;相关性分析显示:糖尿病病程、HbA1c、FIN、FPG、HOMA-IR、空腹C肽、HDL-C、LDL-C、HS-CRP与Asprosin具有相关性。MDA与糖尿病病程、HbA1c、FIN、FPG、HOMA-IR、空腹C肽、LDL-C具有相关性;VEGF与HbA1c、FIN、FPG、HOMA-IR、HDL-C、LDL-C及HS-CRP具有相关性;SOD与糖尿病病程、HbA1c、FPG、FIN、HOMA-IR、HDL-C、LDL-C及HS-CRP具有相关性。4种因子与DR具有相关性,Asprosin预测DR的ROC曲线下面积为0.903,SOD曲线下�Objective To determine the serum levels of adipose factors such as Asprosin,Superoxide Dismutase(SOD),malondialdehyde(MDA)and vascular endothelial growth factor(VEGF)in patients with diabetes retinopathy(DR),and to analyze the correlation between the four factors and DR and oxidative stress.Methods 139 patients with Type 2 diabetes Mellitus(T2DM)hospitalized in the ophthalmology department of the People's Hospital of Inner Mongolia Autonomous Region from November 2022 to October 2023 were selected for the study;The patients were divided into three groups according to DR staging criteria:proliferative diabetes retinopathy(PDR)group(39 cases),non proliferative diabetes retinopathy(NPDR)group(47 cases),diabetes non diabetic retinopathy(NDR)group(53 cases),and simple cataract patients(61 cases)as the control group.The serum levels of Asprosin,SOD,MDA and VEGF were measured by enzyme-linked immunosorbent assay.At the same time,the patient's gender,age,weight,height,BMI,course of diabetes,fasting plasma glucose(FPG),fasting C-peptide,glycosylated hemoglobin(HbA1c),fasting insulin(FIN),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),and total Total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and other indicators,calculate the Homeostatic model assessment of insulin resistance(HOMA-IR),and statistically analyze the above data.Results The serum levels of Asposin,MDA,and VEGF in PDR patients were higher than those in NPDR group and NDR group,all higher than those in NC group.The difference between the two groups was statistically significant;Correlation analysis showed that the course of diabetes HbA1c、FIN、FPG、HOMA-IR、Fasting C-peptide,HDL-C,LDL-C,HS-CRP are correlated with Asposin.MDA and the course of diabetes HbA1c、FIN、FPG、HOMA-IR、There is a correlation between fasting C-peptide and LDL-C;VEGF is correlated with HbA1c,FIN,FPG,HOMA-IR,HDL-C,LDL-C,and HS-CRP;SOD was associated with the course of diabetes,HbA1c,FPG,FIN,HOMA-IR,HDL-C,LDL-C and HS-CRP.Four factors are correlated wit

关 键 词：Asprosin MDA SOD 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]