非甾体抗炎药在267例肺大手术后应用  

Current Status and Rationality Evaluation of Postoperative Use of Nonsteroidal Anti-inflammatory Drugs in 267 Patients Undergoing Major Lung Surgery

作　　者：叶孝 唐叶秋 YE Xiao;TANG Yeqiu(Changshu Hospital Affiliated to Soochow University,Changshu NO.1 People's Hospital,Changshu Jiangsu 215500,China)

机构地区：[1]苏州大学附属常熟医院,常熟市第一人民医院,江苏常熟215500

出　　处：《药品评价》2024年第8期955-959,共5页Drug Evaluation

摘　　要：目的了解苏州大学附属常熟医院胸外科非甾体抗炎药(NSAIDs)使用现状,为促进临床合理用药提供参考。方法采用回顾性调查方法,从医院信息平台获取2022年1月1日至12月31日胸外科行肺大手术出院患者病历,依据所用药品说明书、诊疗指南、专家共识等,对NSAIDs用药情况进行合理性评价,不合理使用NSAIDs的病例归为观察组,未出现不合理使用的设为对照组,比较两组NSAIDs相关性不良反应(ADR)的发生率以及住院时间之间是否有差异。结果总纳入病例267例,观察组148例,对照组119例,观察组出现59例NSAIDs相关性ADR,发生率39.86%,对照组出现31例NSAIDs相关性ADR,发生率为26.05%,观察组的NSAIDs相关性ADR发生率高于对照组,差异有统计学意义(χ^(2)=5.63,P=0.018);观察组平均住院天数多于对照组,差异有统计学意义(P<0.001)。结论肺大手术后不合理的NSAIDs使用会增加NSAIDs相关性ADR的发生风险,还会导致患者的住院时间延长。Objective Investigate the current use of nonsteroidal anti-inflammatory drugs(NSAIDs)in the thoracic surgery department of Changshu Hospital Affiliated to Soochow University,to provide a reference for promoting rational drug use in clinical settings.Methods A retrospective survey was conducted to obtain medical records of patients who underwent major lung surgery in the thoracic surgery department from January 1 to December 31,2022,from the information platform of hospital.Based on the drug instructions,diagnosis and treatment guidelines,expert consensus,etc.,the rationality of NSAIDs medication was evaluated.Cases of unreasonable use of NSAIDs were classified as the observation group,and those who did not experience unreasonable use were set as the control group.The incidence of NSAIDs related adverse reactions(ADRs)and the length of hospital stay were compared between the two groups.Results The total number of cases included was 267,with 148 in the observation group and 119 in the control group.The observation group had 59 cases of NSAIDs related ADR,with an incidence rate of 39.86%,while the control group had 31 cases of NSAIDs related ADR,with an incidence rate of 26.05%.The incidence rate of NSAIDs related ADR in the observation group was higher than that in the control group,and the difference was statistically significant(χ^(2)=5.63,P=0.018).The average length of hospital stay in the observation group was longer than that in the control group,the difference was statistically significant(P<0.001).Conclusion Unreasonable use of NSAIDs after lung surgery increases the risk of NSAID related ADRs and can also lead to prolonged hospital stay for patients.

关 键 词：胸外科 非甾体抗炎药 合理性评价 术后止痛 

分 类 号：R969.3[医药卫生—药理学]