罗伊氏乳杆菌联合消旋卡多曲颗粒对轮状病毒性肠炎患儿肠道菌群的影响  

Effect of Lactobacillus Reuteri Combined with Racecadotril Granules on Intestinal Flora in Children with Rotavirus Enteritis

作　　者：王啸尘 宋莉 陈白璐 WANG Xiaochen;SONG Li;CHEN Bailu(Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院,河南南阳473000

出　　处：《药品评价》2024年第8期959-962,共4页Drug Evaluation

摘　　要：目的分析罗伊氏乳杆菌联合消旋卡多曲颗粒对轮状病毒性肠炎患儿肠道菌群的影响。方法选取2021年5月至2023年9月南阳市中心医院就诊轮状病毒性肠炎患儿120例,根据治疗方案不同分为对照组、联合组。其中予以消旋卡多曲颗粒的60例为对照组,予以罗伊氏乳杆菌联合消旋卡多曲颗粒的60例为联合组。比较两组临床疗效,治疗前后肠道菌群(乳酸杆菌、双歧杆菌、大肠杆菌),T淋巴细胞亚群[表面抗原分化簇4受体(CD4^(+))、CD4^(+)/表面抗原分化簇8受体(CD8^(+)),表面抗原分化簇3受体(CD3^(+))],相关细胞因子[胃动素(MOT)、胃泌素(GAS)、血管活性肠肽(VIP)]水平。结果治疗后,联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05);联合组临床总有效率91.67%高于对照组76.67%(P<0.05);联合组MOT、GAS、VIP水平降低幅度大于对照组(P<0.05);联合组大肠杆菌水平低于对照组,乳酸杆菌、双歧杆菌水平高于对照组(P<0.05)。结论罗伊氏乳杆菌联合消旋卡多曲颗粒治疗轮状病毒性肠炎患儿疗效显著,可调节肠道菌群,改善免疫功能及胃肠激素。Objective To analyze the effect of Lactobacillus reuteri combined with racecadotril granules on intestinal flora in children with rotavirus enteritis(RE).Methods A total of 120 children with RE in Nanyang Central Hospital from May 2021 to September 2023 were selected,divided into control group and combined group according to different treatment schemes.Among them,60 cases were given racecadotril granules as the control group,and 60 cases were given Lactobacillus reuteri combined with racecadotril granules as the combined group.The clinical efficacy of the two groups was compared,as well as the levels of intestinal flora(Lactobacillus,Bifidobacterium,Escherichia coli),T lymphocyte subsets[surface antigen differentiation cluster 4 receptor(CD4^(+)),CD4^(+)/surface antigen differentiation cluster 8 receptor(CD8^(+)),surface antigen differentiation cluster 3 receptor(CD3^(+))]and related cytokines[motilin(MOT),gastrin(GAS),vasoactive intestinal peptide(VIP)]before and after treatment.Results After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the combined group were higher than those in the control group(P<0.05);the total effective rate of the combined group was 91.67%higher than 76.67%of the control group(P<0.05);the levels of MOT,GAS and VIP in the combined group were significantly lower than those in the control group(P<0.05);the level of Escherichia coli in the combined group was lower than that in the control group,while the levels of Lactobacillus and Bifidobacterium in the combined group were higher than those in the control group(P<0.05).Conclusion The curative effect of Lactobacillus reuteri combined with racecadotril granules in the treatment of children with RE is significant,which can regulate intestinal flora,improve immune function and gastrointestinal hormones.

关 键 词：罗伊氏乳杆菌 消旋卡多曲颗粒 轮状病毒性肠炎 肠道菌群 相关细胞因子 

分 类 号：R725.7[医药卫生—儿科]