硫辛酸联合己酮可可碱对老年糖尿病周围神经病变患者神经传导速度的影响  

Effect of Thioctic Acid Combined with Pentoxifylline on Nerve Conduction Velocity in Elderly Patients with Diabetic Peripheral Neuropathy

作　　者：王培华 宫凤云 WANG Peihua;GONG Fengyun(Henan(Zhengzhou)Modern Medical Research Institute Traditional Chinese Medicine Hospital,Zhengzhou Henan 450006,China;Zhengzhou People's Hospital,Zhengzhou Henan 451100,China)

机构地区：[1]河南(郑州)现代医学研究院中医院,河南郑州450006 [2]郑州市人民医院,河南郑州451100

出　　处：《药品评价》2024年第8期971-974,共4页Drug Evaluation

摘　　要：目的研究硫辛酸联合己酮可可碱对老年糖尿病周围神经病变(DPN)患者神经传导速度的影响。方法前瞻性选取2022年1月至2023年12月河南(郑州)现代医学研究院中医院收治的老年DPN患者92例,以随机数字表法分为联合组48例、单一组44例。单一组采用己酮可可碱治疗,联合组采用硫辛酸联合己酮可可碱治疗。比较两组临床疗效、正中神经F波、多伦多临床评分系统(TCSS)及密歇根神经病变筛选表(MNSI)评分、氧化应激指标、不良反应总发生率。结果联合组总有效率(93.75%)高于单一组(77.27%)(P<0.05),且两组不良反应总发生率比较,差异无统计学意义(P>0.05);治疗后两组正中神经F波、氧化应激指标、TCSS及MNSI评分均改善,且联合组优于单一组(P<0.05)。结论硫辛酸联合己酮可可碱治疗老年DPN患者效果显著,可有效地提高神经传导速度,减轻氧化应激反应,且具有一定安全性。Objective To study the effect of thioctic acid combined with pentoxifylline on nerve conduction velocity in patients with diabetic peripheral neuropathy(DPN).Methods Ninety-two elderly patients with DPN were selected and treated in Henan(Zhengzhou)Modern Medical Research Institute Traditional Chinese Medicine Hospital from January 2022 to December 2023.They were randomly divided into a combined group of 48 patients and a single group of 44 patients using a random number table method.The single group was treated with pentoxifylline,while the combined group was treated with thioctic acid combined with pentoxifylline.The clinical efficacy,median nerve F-wave,Toronto Clinical Scoring System(TCSS)and Michigan Neuropathy Screening Instrument(MNSI)scores,oxidative stress indicators,and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of the combined group(93.75%)was higher than that of the single group(77.27%)(P<0.05),and there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05);after treatment,the F-wave,oxidative stress index,TCSS,and MNSI scores of the two groups improved,and the combined group was superior to the single group(P<0.05).Conclusion Thioctic acid combined with pentoxifylline in the treatment of elderly patients with DPN has significant effect,can effectively improve nerve conduction velocity,reduce oxidative stress reaction,and has certain safety.

关 键 词：硫辛酸 己酮可可碱 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌] R747.9[医药卫生—内科学]