四联抗结核方案联合莫西沙星治疗难治性肺结核的效果及机制  

The efficacy and mechanism of quadruple anti tuberculosis regimen combined with moxifloxacin in the treatment of refractory pulmonary tuberculosis

作　　者：李娜 LI Na(Heze Infectious Disease Hospital,Heze 274000,Shandong)

机构地区：[1]菏泽市传染病医院,山东菏泽274000

出　　处：《菏泽医学专科学校学报》2024年第4期33-35,39,共4页Journal of Heze Medical College

摘　　要：目的 研究四联抗结核方案联合莫西沙星治疗难治性肺结核(PTB)的效果及机制。方法 选择我院收治的难治性PTB患者75例,随机分为两组,对照组37例,观察组38例。对照组实施四联抗结核方案治疗,观察组在对照组基础上实施莫西沙星联合治疗。比较两组近期疗效以及治疗前后机体炎症状态(白细胞介素-6、肿瘤坏死因子-α、C反应蛋白)、肺功能(用力肺活量、第一秒用力呼气容积、用力肺活量与第一秒用力呼气容积比值)、血气分析指标(二氧化碳分压、氧分压、脉搏血氧饱和度)的变化。结果 两组疗效比较,P<0.05。两组治疗后白细胞介素-6、肿瘤坏死因子-α、C反应蛋白水平比较,P<0.05。两组治疗后用力肺活量、第一秒用力呼气容积、用力肺活量与第一秒用力呼气容积比值比较,P <0.05。两组治疗后二氧化碳分压、氧分压、脉搏血氧饱和度比较,P <0.05。结论 四联抗结核方案联合莫西沙星能够提高PTB患者的近期疗效,可能与其能够减轻患者机体炎症状态,改善肺功能及血气分析指标的异常等药学机制有关。Objective To investigate the efficacy and mechanism of quadruple anti tuberculosis regimen combined with moxifloxacin in the treatment of refractory pulmonary tuberculosis(PTB).Methods 75 patients with PTB admitted to our hospital were selected and randomly divided into the control group(37 cases)and the observation group(38 cases).The control group received quadruple anti tuberculosis treatment,while the observation group received moxifloxacin combination therapy on the basis of the control group.The recent therapeutic effect,inflammatory state of organism(interleukin-6,tumor necrosis factor-α,C-reactive protein),lung function(forced vital capacity,first second forced expiratory volume,ratio of forced vital capacity to first second forced expiratory volume),and blood gas analysis indicators(partial pressure of carbon dioxide,partial pressure of oxygen,pulse oximetry)before and after treatment were compared between the two groups.Results The comparison of efficacy between the two groups showed statistically significant difference(P<0.05).The comparison of inflammatory state,lung function and arterial blood gas analysis between the two groups after treatment showed statistically significant difference(P<0.05).Conclusion The combination of quadruple anti tuberculosis regimen and moxifloxacin can improve the short-term efficacy of patients with refractory PTB,which may be related to its pharmacological mechanism of reducing the inflammatory state,improving lung function and abnormal blood gas analysis indicators.

关 键 词：四联抗结核方案 莫西沙星 难治性肺结核 疗效 机制 

分 类 号：R521[医药卫生—内科学]