恩替卡韦治疗慢性乙肝并2型糖尿病疗效及肾脏安全性研究  

Efficacy and renal safety of entecavir in the treatment of chronic hepatitis B complicated with type 2 diabetes

作　　者：贾婷 杨晓冬 高斯媛 李俊义 马仲序 段劲宇 JIA Ting;YANG Xiaodong;GAO Siyuan;LI Junyi;MA Zhongxu;DUAN Jingyu(Second Department of Hepatology,Third People's Hospital of Kunming/Yunnan Provincial Clinical Medical Center for Infectious Diseases,Kunming Yunnan 650041,China;Department of General Medicine,Third People's Hospital of Kunming/Yunnan Provincial Clinical Medical Center for Infectious Diseases,Kunming Yunnan 650041,China;Information Department,Third People's Hospital of Kunming/Yunnan Provincial Clinical Medical Center for Infectious Diseases,Kunming Yunnan 650041,China)

机构地区：[1]昆明市第三人民医院/云南省传染性疾病临床医学中心肝病二科,云南昆明650041 [2]昆明市第三人民医院/云南省传染性疾病临床医学中心综合内科,云南昆明650041 [3]昆明市第三人民医院/云南省传染性疾病临床医学中心信息科,云南昆明650041

出　　处：《云南医药》2024年第6期17-20,共4页Medicine and Pharmacy of Yunnan

基　　金：昆明市科技计划项目(2022-03-08-010)。

摘　　要：目的探讨恩替卡韦治疗慢性乙型肝炎合并2型糖尿病疗效及肾脏安全性研究。方法选取2021年2月-2023年2月本院收治的72例慢性乙型肝炎合并2型糖尿病患者,分为2组。对照组用富马酸替诺福韦酯治疗,研究组用恩替卡韦治疗。观察分析2组临床疗效、肾功能、糖脂代谢、肝功能等情况。结果与对照组比,研究组临床疗效好、SCr及BUN水平低、eGFR水平高、FBG、HbA1c水平低、ALT、AST和TBIL水平低,差异均有统计学意义(P<0.05)。结论患者采用恩替卡韦治疗能够取得较为理想的抗病毒治疗效果,对肾脏具有较高的安全性,值得应用。Objective To investigate the efficacy and renal safety of entecavir in the treatment of chronic hepatitis B(CHB)complicated with type 2 diabetes mellitus(T2DM).Methods A total of 72 patients with CHB complicated with T2DM admitted to our hospital from February 2021 to February 2023 were divided into two groups.The control group was treated with tenofovir fumarate,and the study group was treated with entecavir.Clinical efficacy,renal function,glucose and lipid metabolism and liver function of the two groups were observed and analyzed.Results Compared with the control group,the clinical effect of the study group was better,SCr and BUN levels were lower,eGFR levels were higher,FBG and HbA1c levels were lower,ALT,AST and TBIL levels were lower,and the differences were statistically significant(P<0.05).Conclusions Patients treated with entecavir can achieve a relatively ideal antiviral treatment effect,and has a high safety on the kidney,which is worthy of application.

关 键 词：恩替卡韦 慢性乙肝 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌] R512.62[医药卫生—内科学] R692.9[医药卫生—临床医学]