结核丸治疗复治肺结核疗效和安全性的Meta分析  

Meta-analysis of the efficacy and safety of tuberculosis pills in the treatment of retreatment tuberculosis

作　　者：李花蓉 樊浩 刘幸 吴雪娇 姚晓蝶 沈磊 LI Huarong;FAN Hao;LIU Xing;WU Xuejiao;YAO Xiaodie;SHEN Lei(School of Pharmacy,Dali University,Dali Yunnan 671000,China;Department of Pharmacy,Kunming Third People's Hospital/Yunnan Clinical Center for Infectious Diseases,Kunming Yunnan 650041,China;Department of Pharmacy,Northeast Yunnan Regional Central Hospital of Yunnan Province,Zhaotong Yunnan 657000,China;Department of Pharmacy,Yiliang County People's Hospital,Zhaotong Yunnan 657000,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]昆明市第三人民医院/云南省传染性疾病临床医学中心药学部,云南昆明650041 [3]云南省滇东北区域中心医院药剂科,云南昭通657000 [4]彝良县人民医院药剂科,云南昭通657000

出　　处：《云南医药》2024年第6期43-48,共6页Medicine and Pharmacy of Yunnan

基　　金：云南省教育厅科学研究基金资助项目(2024J0897)。

摘　　要：目的探索结核丸联合常规抗结核方案治疗复治肺结核的循证医学证据。方法通过计算机检索VIP、CNKI、WangFang、CBM、PubMed、Embase等数据库,搜集结核丸治疗复治肺结核的随机对照实验,检索时间为建库至2024年1月10日。由2名研究者独立文献筛选、资料提取,使用Corchrane 5.3偏倚风险评估工具对纳入的文献进行质量评价,使用Review Manager 5.3软件进行统计学分析。结果共纳入15个RCT,共1584例患者进行Meta分析。结果显示:结核丸联用常规抗结核方案治疗复治肺结核,在临床症状改善率、痰菌转阴率、病灶吸收率、空洞闭合率方面均优于单用常规抗结核方案,单用常规抗结核方案的不良反应发生率高于联合用药,差异具有统计学意义(P<0.05)。结论结核丸联用常规抗结核方案治疗复治肺结核的整体疗效优于单用常规抗结核方案治疗。Objective To explore the evidence-based medical evidence of tuberculosis pills combined with conventional anti-tuberculosis regimen in the treatment of recurrent pulmonary tuberculosis.Methods Through searching VIP,CNKI,WangFang,CBM,PubMed,Embase and other databases,the randomized controlled trials of tuberculosis pills in the treatment of retreated pulmonary tuberculosis were collected from the time of database construction to January 10th,2024.Two researchers conducted independent literature screening and data extraction,and the Corchrane 5.3 bias risk assessment tool was used to evaluate the quality of the include literature,statistical analysis was performed using Review Manager 5.3 software after.Results A total of 15 RCTs with 1584 patients were included in the meta-analysis.The results showed:the combination of TB pills with conventional anti-TB regimens for the treatment of recurrent TB was better than conventional anti-TB regimens alone in terms of clinical symptom improvement rate,sputum negative conversion rate,lesion absorption rate and cavity closure rate,the incidence of adverse reactions of conventional anti-TB regimens alone was higher than that of combined regimen,and the difference was statistically significant(P<0.05).Conclusions The overall efficacy of tuberculosis pills combined with conventional anti-tuberculosis regimen in the treatment of recurrent tuberculosis is better than that of conventional anti-tuberculosis regimen alone.

关 键 词：复治肺结核 结核丸 META分析 中成药 

分 类 号：R521[医药卫生—内科学]