化瘀续折方联合MIPO技术对闭合性胫骨中下段骨折(气滞血瘀证)TNF-α、β-EP、IL-6及骨代谢指标的影响  

Effects of combining the Huayu Xuzhe decoction with the MIPO technique on TNF-α,β-EP,IL-6 and bone metabolic indexes in closed middle and lower tibial fractures(Qi Stagnation and Blood Stasis Syndrome)

作　　者：蔡军和 王剑锋[1] 顾豪杰[1] 宋海波[1] 叶晶华[1] CAI Junhe;WANG Jianfeng;GU Haojie(Department of Orthopedics,Haining City Hospital of Traditional Chinese Medicine,Jiaxing 314400,China)

机构地区：[1]海宁市中医院骨伤科,浙江嘉兴314400

出　　处：《全科医学临床与教育》2024年第12期1096-1098,1111,共4页Clinical Education of General Practice

摘　　要：目的探讨化瘀续折方联合微创接骨板内固定(MIPO)技术在闭合性胫骨中下段骨折(气滞血瘀证)治疗中的应用价值。方法选择闭合性胫骨中下段骨折(气滞血瘀证)128例,按照随机数字表法分为两组,两组均64例。对照组采用MIPO技术等西医治疗手段,观察组联合化瘀续折方治疗,治疗4周后比较疗效。结果治疗后,观察组患者的血清β-内啡肽(β-EP)、护骨素(OPG)水平高于对照组,肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、5-羟色胺(5-HT)、β-胶原特殊序列(β-CTX)水平均低于对照组,差异均有统计学意义(t分别=-7.69、-9.21、11.09、20.06、10.64、18.49,P均<0.05);治疗后,观察组中医总症状积分、骨折愈合时间、术后下床时间均低于对照组,踝-后足评分高于对照组,差异均有统计学意义(t分别=8.25、9.21、6.84、-20.83,P均<0.05);观察组踝关节功能总优良率98.44%,高于对照组的85.94%,差异有统计学意义(χ^(2)=6.94,P<0.05)。结论对于闭合性胫骨中下段骨折(气滞血瘀证)患者,采用化瘀续折方用联合MIPO技术治疗有助于减轻炎症反应,调节骨代谢,促进骨折愈合,提高临床疗效。Objective To explore the application value of Huayu Xuzhe decoction combined with MIPO technology in the treatment of closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome).Methods A total of 128 cases of closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome)were selected and divided into two groups according to the random number table method,64 cases in each groups.The control group was treated with MIPO technology,and the observation group was treated with Huayu Xuzhe decoction combined with MIPD technology,and the efficacy was compared after 4 weeks of treatment.Results After treatment,the serum levels ofβ-endorphins(β-EP)and osteoprotegerin(OPG)in the observation group were higher than those in the control group,while the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),5-hydroxytryptamine(5-HT)andβ-collagen special sequence(β-CTX)in the observation group were lower than those in the control group,and the differences were statistically significant(t=-7.69,-9.12,11.09,20.06,10.64,18.49,P<0.05).After treatment,the total symptom score,fracture healing time and time off bed after surgery in the observation group were lower than those in the control group,while the ankle-hindfoot score in the observation group was higher than that in the control group,and the differences were statistically significant(t=8.25,9.21,6.84,-20.83,P<0.05).The total excellent rate of ankle joint function in the observation group was 98.44%,which was higher than that of the control group(85.94%),and the difference was statistically significant(χ^(2)=6.94,P<0.05).Conclusion For patients with closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome),the Huayu Xuzhe decoction combined with MIPO technology can help to reduce inflammation,regulate bone metabolism,promote fracture healing,and improve clinical efficacy.

关 键 词：化瘀续折方 微创接骨板内固定技术 闭合性胫骨中下段骨折 气滞血瘀证 

分 类 号：R687.3[医药卫生—骨科学]