自身免疫性疾病口腔表现及诊治策略的研究进展  

Research progress in oral manifestations,diagnosis and treatment of autoimmune diseases

作　　者：王倩 赵岩 金建秋[1] Wang Qian;Zhao Yan;Jin Jianqiu(Department of Stomatology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases,Ministry of Science&Technology,State Key Laboratory of Complex Severe and Rare Diseases,Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education,Beijing 100730,China)

机构地区：[1]北京医院口腔科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [2]中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,国家皮肤与免疫疾病临床医学研究中心,疑难重症及罕见病国家重点实验室,风湿免疫病学教育部重点实验室,北京100730

出　　处：《中国医学前沿杂志（电子版）》2024年第11期31-38,I0002,共9页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家重点研发计划资助(2023YFC3605600);中央高水平医院临床科研业务费(BJ-2023-187)。

摘　　要：机体对自身抗体发生免疫反应,从而导致自身组织损害所引起的疾病称为自身免疫性疾病(autoimmune diseases,ADs)。ADs特点为复杂多变,可造成局部或多器官损害。常见病种有系统性红斑狼疮、类风湿关节炎、干燥综合征、硬皮病、白塞综合征、免疫性血小板减少症、天疱疮、黏膜类天疱疮、副肿瘤性天疱疮和炎症性肠病等。口腔症状常为ADs的首发表现。本文对常见的出现口腔症状的ADs及其相应诊治策略的研究进展进行综述,进一步提高各科医生对ADs临床早期诊疗的效率。Autoimmune diseases(ADs)are caused by the body's immune response to its own components,resulting in tissue damage.The disease characteristics of ADs are complex and variable,and can cause local or multiple organ damage.The common diseases of ADs include systemic lupus erythematosus(SLE),rheumatoid arthritis,Sjögren's syndrome,scleroderma,Behcet syndrome,primary immune thrombocytopenia,pemphigus,mucosal pemphigoid,paraneoplastic pemphigus and inflammatory bowel disease,etc.Oral symptoms are often the first manifestation of ADs.This article reviews the research progress on ADs with common oral symptoms and corresponding diagnosis and treatment strategies,which is helpful to improve the efficiency of early clinical diagnosis and treatment of ADs.

关 键 词：自身免疫性疾病 口腔表现 早期诊断 

分 类 号：R593.2[医药卫生—内科学] R781[医药卫生—临床医学]