长链非编码核糖核酸在肺结核疾病病程中的作用及研究进展  

The role and research progress of long non-coding RNA in the course of tuberculosis

作　　者：姚思雨 刘秋月[1] Yao Siyu;Liu Qiuyue(Department of Critical Care Medicine,Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所重症医学科,北京101149

出　　处：《中国医学前沿杂志（电子版）》2024年第11期85-91,I0003,共8页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(82100011)。

摘　　要：肺结核是由结核分枝杆菌感染人体肺部引起的传染性疾病,在结核病中最为常见。由于早期诊断不及时、误诊、治疗不当、延误治疗以及患者自身免疫状况等因素可促使结核病进展为重症,增加患者死亡风险。长链非编码核糖核酸(long non-coding RNA,lnc RNA)已成为影响疾病诊断、治疗和预后的潜在新型分子,且在肺结核领域诊治方面展示出了很大的潜力和优势,其中部分研究探讨了lnc RNA在监测肺结核向重症发展过程中的潜在作用。本文就lnc RNA在肺结核疾病进展中发挥的生物学功能进行综述,探讨lnc RNA作为肺结核向重症进展的分子生物标志物和诊治靶点的前景。Pulmonary tuberculosis is an infectious disease caused by the infection of Mycobacterium tuberculosis in the human lungs,which is the most common type of tuberculosis.Factors such as delayed early diagnosis,misdiagnosis,inappropriate treatment,delayed treatment and patients'autoimmune status worsen the disease and increase the risk of death.Long non-coding RNA(lncRNA)has emerged as potential new molecules affecting the diagnosis,treatment and prognosis of diseases,and has shown great potential and advantages in the diagnosis and treatment of pulmonary tuberculosis.Some studies have explored the potential role of lncRNA and their potential in monitoring the development of severe pulmonary tuberculosis.This article explores the biological functions of lncRNA in the progression of pulmonary tuberculosis,and the prospect of lncRNA as molecular biomarkers and targets for diagnosis and treatment of severe pulmonary tuberculosis is discussed.

关 键 词：结核病 重症肺结核 长链非编码核糖核酸 

分 类 号：R521[医药卫生—内科学]