基于文献研究探讨清热化痰法治疗慢性阻塞性肺疾病急性加重期的用药规律  

The Study of Prescription Rule of AECOPD Treated by Clearing Heat and Resolving Phlegm Based on Literature Research

作　　者：方路敏 和春芳[2] 曹凡洲 FANG Lumin;HE Chunfang;CAO Fanzhou(Kunming Traditional Chinese Medicine Hospital,Kunming 650011,China;Yunnan Traditional Chinese Medicine Hospital,Kunming 650021,China)

机构地区：[1]云南省昆明市中医医院,云南昆明650000 [2]云南省中医医院,云南昆明650021

出　　处：《中国民族民间医药》2024年第23期71-80,共10页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:基于文献研究探讨现代医家以清热化痰法治慢性阻塞性肺疾病急性加重期(AECOPD)的用药规律。方法:系统检索万方、PubMed等数据库中清热化痰法治疗AECOPD的相关文献,获取组方数据,采用IBM SPSS Modeler 18.0等软件进行一般情况、关联规则和聚类分析,探求其潜在用药规律。结果:纳入360个处方,共计175味中药,高频中药55味,功效以清热、止咳化痰平喘等为主,清热化痰法可细分为“清热化痰理气”等7种治法,四气以寒、温为主,五味以苦、辛、甘为主,归经以肺、脾、胃为主,核心对药13个,核心角药25个,核心处方13个。结论:清热化热法治疗AECOPD(痰热壅肺证)在清热化痰法的基础下可细分为清热化痰理气、清热化痰解表、清热化痰活血等7个治法,可据临床实际灵活运用,并发现“黄芩、桑白皮、贝母”这一重要角药。Objective To analyze prescription rule of the acute exacerbation of chronic obstructive pulmonary disease in the treatment with clearing heat and resolving phlegm.Methods Screen literatures and extract data of the AECOPD treated by clearing heat and resolving method in the Wangfang date and other data bases from their establishment to October 2022,and use IBM SPSS Statistics 25.0 and IBM SPSS Modeler 18.0 to find out the medication rule.Results A total of 360 prescriptions were obtain,including 123 TCM herbs,the herbs with high frequency were 55,and main function is clearing heat,relieving cough,reducing phlegm and relieving asthma,further study find that Clearing Heat and Resolving Phlegm method can be sorted out 7 methods;13 core Pair medicine,25 core horn medicine and 13 core prescriptions were found out.Conclusion AECOPD(syndrome of phlegm-heat obstructing lung)can sort out 8 treatment methods based on Clearing Heat and Resolving Phlegm method,and also find an important horn medicine(baicalensis,mori cortex and caladium).

关 键 词：清热化痰法 数据挖掘 AECOPD 用药规律 

分 类 号：R259[医药卫生—中西医结合]