中西医结合治疗慢阻肺合并阻塞性睡眠呼吸暂停低通气综合征56例临床观察  

Clinical Observation on 56 Cases of Combined Chinese and Western Medicine Treatment of Chronic Obstructive Pulmonary Disease Combined with Obstructive Sleep Apnea and Hypoventilation Syndrome

作　　者：何金星 HE Jinxing(Nanning Wuming District Traditional Chinese Medicine Hospital,Nanning 530199,China)

机构地区：[1]南宁市武鸣区中医医院,广西南宁530199

出　　处：《中国民族民间医药》2024年第23期114-118,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:观察中西医结合治疗慢性阻塞性肺疾病(COPD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)56例临床效果。方法:选取收治的COPD合并OSAHS患者112例,将上述COPD合并OSAHS患者采用简单随机法均分为两组,单组56例。两组均给予呼吸肌功能训练、肢体功能锻炼干预,对照组给予常规对症治疗,观察组给予补中化瘀益肺汤辅助常规治疗。评估两组中医证候积分、Epworth嗜睡量表(ESS)评分,检测两组凝血-纤溶功能、心肺功能试验(CPET)参数、多导睡眠(PSG)检测结果,统计两组疗效。结果:治疗前比较两组中医证候积分、ESS评分,无统计学差异(P>0.05)。两组中医证候积分、ESS评分治疗8周后低于治疗前,且观察组低于对照组(P<0.05)。治疗前比较两组凝血-纤溶功能、PSG检测结果,无统计学差异(P>0.05)。两组纤维蛋白原(Fib)、呼吸紊乱指数(AHI)、D-二聚体治疗8周后低于治疗前,活化部分凝血活酶时间(APTT)、夜间最低血氧饱和度(LSaO_(2))和平均血氧饱和度(MSaO_(2))、凝血酶原时间(PT)治疗8周后高于治疗前,且观察组Fib、D-二聚体低于对照组,APTT、夜间LSaO_(2)和MSaO_(2)、PT高于对照组(P<0.05)。治疗前比较两组CPET参数,无统计学差异(P>0.05)。两组二氧化碳通气当量(VE/VCO_(2))治疗8周后低于治疗前,摄氧量功率比值(VO_(2)/WR)、无氧阈值(AT)、最大摄氧量占预计值百分比(VO_(2max)%pred)、呼吸储备(VE_(max)/MVV)治疗8周后高于治疗前,且观察组VE/VCO_(2)低于对照组,VO_(2)/WR、AT、VO_(2max)%pred、VE max/MVV高于对照组(P<0.05)。观察组总有效率高于对照组,有统计学差异(P<0.05)。结论:中西医结合治疗COPD合并OSAHS可调节凝血-纤溶功能,改善心肺功能,提高疗效。Objective To observe the clinical effects of combined Chinese and Western medicine in the treatment of 56 cases of chronic obstructive pulmonary disease(COPD)combined with obstructive sleep apnea hypoventilation syndrome(OSAHS).Methods 112 patients with COPD combined with OSAHS were selected,and the above patients with COPD combined with OSAHS were divided into two groups by simple randomization method,with 56 cases in a single group.Both groups were given respiratory muscle functional training and limb functional exercise interventions,the control group was given conventional symptomatic treatment,and the observation group was given supplemental conventional treatment with tonifying the middle and eliminating blood stasis and benefiting the lung soup.The two groups were evaluated for TCM evidence points,Epworth Sleepiness Scale(ESS)scores,and the results of coagulation-fibrinolytic function,cardiopulmonary function test(CPET)parameters,and polysomnography(PSG)test were detected to statistically measure the efficacy of the two groups.Results Comparing the TCM evidence points and ESS scores of the two groups before treatment,there was no statistical difference(P>0.05).The TCM evidence points and ESS scores of the two groups were lower than those before treatment after 8 weeks of treatment,and the observation group was lower than the control group(P<0.05).There was no statistical difference when comparing the results of coagulation-fibrinolytic function and PSG test between the two groups before treatment(P>0.05).Fibrinogen(Fib),respiratory disturbance index(AHI)and D-dimer were lower than before treatment after 8 weeks of treatment in both groups,activated partial thromboplastin time(APTT),nighttime minimum saturation of oxygen(LSaO_(2))and mean saturation of oxygen(MSaO_(2)),and plasminogen time(PT)were higher than before treatment after 8 weeks of treatment,and Fib and D-dimer were lower than in the control group in the observation group.APTT,nocturnal LSaO_(2) and MSaO_(2),PT were higher than the control group(

关 键 词：补中化瘀益肺汤 慢性阻塞性肺疾病 凝血-纤溶功能 心肺功能 阻塞性睡眠呼吸暂停低通气综合征 疗效 

分 类 号：R563[医药卫生—呼吸系统]