Ginsenoside Rb_(1) in cardiovascular and cerebrovascular diseases:A review of therapeutic potentials and molecular mechanisms  

作　　者：Yueqin Song Chen Chen Wei Li 

机构地区：[1]College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China [2]School of Biomedical Sciences,University of Queensland,Brisbane,QLD 4072,Australia [3]College of Life Sciences,Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development,Jilin Agricultural University,Changchun 130118,China [4]Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials,Changchun 130118,China

出　　处：《Chinese Herbal Medicines》2024年第4期489-504,共16页中草药（英文版）

基　　金：supported by the grants of National Natural Science Foundation of China (No. 82104465)。

摘　　要：Cardiovascular and cerebrovascular diseases(CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the improvement of economic level and the change of human lifestyle, the prevalence of CCVDs continues to increase. Ginseng(Panax ginseng C. A. Mey.) was widely used in traditional diseases due to its supposed tonic properties. Ginsenoside Rb_(1) (G-Rb_(1) ) is the most abundant active ingredient with multiple pharmacological effects extracted from ginseng, which has been shown to have potential benefits on the cardiovascular system through a variety of mechanisms, including anti-oxidation, antiinflammatory, regulation of vasodilation, reduction of platelet adhesion, influence of calcium ion channels, improvement of lipid distribution, involving in glucose metabolism and controlling blood sugar.This review reviewed the protective effects of G-Rb_(1) on CCVDs and its potential mechanisms, such as atherosclerosis(AS), hypertension, coronary heart disease(CHD), ischemic stroke(IS) and periocular microvascular retinopathy. Finally, we reviewed and reported the results of in vivo and in vitro experiments using G-Rb_(1) to improve CCVDs, highlighted its efficacy, safety, and limitations.

关 键 词：atherosclerosis cardiovascular and cerebrovascular diseases coronary heart disease ginsenoside Rb_(1) hypertension ischemic stroke periocular microvascular retinopathy 

分 类 号：R285[医药卫生—中药学]