Toll样受体激动剂及其作为寄生虫疫苗佐剂研究进展  

Research progress in Toll-like receptor agonist types and applications as adjurants for parasitics vaccine

作　　者：王丹妮 郑贵杰 张翼 韩艳辉 王松[1] 朱惠丽[1] WANG Dan-ni;ZHENG Gui-jie;ZHANG Yi;HAN Yan-hui;WANG Song;ZHU Hui-li(College of Animal Science and Veterinary Medicine,Henan Institute of Science and Technology,Xinxiang 453003,China)

机构地区：[1]河南科技学院动物科技学院,新乡453003

出　　处：《中国人兽共患病学报》2024年第11期1063-1072,共10页Chinese Journal of Zoonoses

基　　金：河南省科技攻关项目(No.242102110017)资助。

摘　　要：Toll样受体(Toll-like receptor,TLR)作为启动固有免疫应答的关键分子,是连接固有免疫和适应性免疫应答的桥梁。TLR属于跨膜受体,主要由天然免疫细胞表达,分为细胞表面TLR和细胞内TLR。TLR的配体称为TLR激动剂,研究发现TLR激动剂作为佐剂可提高疫苗的免疫保护效应。由于寄生虫生活史复杂,不同虫种或同一虫种不同发育阶段的抗原特性差异给寄生虫疫苗的研制与开发带来严重困难,因此研发有效、安全的新型佐剂对提高寄生虫疫苗免疫效果至关重要。本文对TLR激动剂的种类和作用以及作为寄生虫疫苗佐剂的应用进行综述,为新型寄生虫疫苗佐剂的研发提供新的思路。Toll-like receptors(TLRs),key molecules initiating innate immune responses,serve as a bridge linking innate and adaptive immune responses.TLRs are transmembrane receptors expressed probably by natural immune cells,and are divided into cell surface and intracellular TLRs.Several studies have indicated that TLR agonists as adjuvants can enhance the immune protective effects of vaccines.Because of the complex life history of parasites and the differences in antigen characteristics among species or developmental stages in the same species,the research and development of parasite vaccines is challenging.Therefore,the development of effective and safe new adjuvants is crucial for improving the immune efficacy of parasite vaccines.This article reviews the types and effects of TLR agonists,as well as their applications as adjuvants for parasitic vaccines,to provide new ideas for the development of new parasitic vaccine adjuvants.

关 键 词：TOLL样受体 激动剂 疫苗 佐剂 

分 类 号：R38[医药卫生—医学寄生虫学]