鹦鹉热衣原体感染的临床特征和下呼吸道微生物群分析  

Clinical characteristics and lower respiratory tract microbiota analysis of Chlamydia psittaci infection

作　　者：朱心雨 陈嫱 赖兰敏 刘洋[1] 赵锐 袁磊 ZHU Xin-yu;CHEN Qiang;LAI Lan-min;LIU Yang;ZHAO Rui;YUAN Lei(Department of Clinical Laboratory,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330000,China)

机构地区：[1]南昌大学第一附属医院检验科,南昌330000

出　　处：《中国人兽共患病学报》2024年第11期1099-1106,共8页Chinese Journal of Zoonoses

基　　金：江西省教育厅基金项目(No.GJJ190055);江西省自然科学基金项目(No.20242BAB20430)。

摘　　要：目的探讨鹦鹉热衣原体肺炎的临床特点和下呼吸道微生物群特征。方法回顾性分析南昌大学第一附属医院2021年1月至12月采用宏基因组二代测序技术(mNGS)确诊的27例鹦鹉热衣原体肺炎的诊治过程,记录患者的临床表现、实验室检查、胸部CT表现、治疗和预后等。结果在27例鹦鹉热衣原体肺炎病例中,20例患者有明确禽类接触史。重症患者D-二聚体水平显著高于非重症患者。胸部CT扫描显示59.3%重症组患者有双侧肺病变(59.3%)明显多于非重症组。两组的下呼吸道微生物物种分布不同。非重症组和重症组的下呼吸道微生物群多样性分析无统计学差异。物种丰度分析发现2组的鹦鹉热衣原体、副流感嗜血杆菌、澳大利亚链球菌和肺炎链球菌物种丰度差异有统计学差异。结论重症鹦鹉热衣原体感染患者下呼吸道的微生物组成发生改变。This study retrospectively analyzed the diagnosis and treatment of 27 cases of Chlamydia psittaci pneumonia diagnosed through metagenomic second-generation sequencing(mNGS)at the First Affiliated Hospital of Nanchang University between January and December 2021.The clinical manifestations,laboratory tests,chest CT findings,treatment,and prognosis of the patients were recorded.Among 27 cases of Chlamydia psittaci pneumonia,20 patients had a clear history of contact with poultry.The D-dimer level was significantly higher in critically ill patients than non-critically ill patients.Chest CT scans showed that 59.3%of patients in the severe group had bilateral lung lesions-a percentage significantly higher than that in the non-severe group.Analysis of the lower respiratory tract microbiota between groups revealed that the distribution of microbial species differed,but no significant differences were observed in diversity analysis.Species abundance analysis revealed statistical differences in the species abundance of Chlamydia psittaci,Haemophilus parainfluenzae,Streptococcus Australis,and Streptococcus pneumoniae between groups.Thus,the microbial composition in the lower respiratory tract in patients with severe Chlamydia psittaci infection showed changes.

关 键 词：鹦鹉热衣原体 宏基因组二代测序技术 临床特征 下呼吸道微生物群 

分 类 号：R374.2[医药卫生—病原生物学]