核医学分子探针在肝纤维化诊断和分期中的研究进展  

Research progress of nuclear molecular probes in the diagnosis and staging of hepatic fibrosis

作　　者：黄文鹏 彭雨硕 宋乐乐 康磊[1] Huang Wenpeng;Peng Yushuo;Song Lele;Kang Lei(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《国际放射医学核医学杂志》2024年第10期644-650,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金面上项目(82171970);北京市杰出青年项目(JQ21025)。

摘　　要：肝纤维化是在慢性肝损伤后,肝脏进行的一种损伤修复反应。肝纤维化的无创性评估和分期对患有慢性肝病患者的病情评估具有重要意义,同时,肝纤维化的精确定量分析在评估肝硬化程度、衡量创新疗法的有效性以及确定适当的治疗方法方面起着关键作用,对患者的预后具有深远影响。传统上通过侵入性肝活体组织检查对肝纤维化进行分期,但这种方法存在有创、易导致并发症以及由于病变分布不均而导致的取样误差等局限性。无创性影像检查技术具有灵敏度高、更全面、可定量等优点,目前已成为评估肝纤维化的有力工具,其中核医学分子影像技术可在分子水平上直接表征、量化探针与靶点结合后的代谢变化等信息,进而量化肝纤维化的病理生理过程。笔者对核医学分子探针在肝纤维化研究中的最新发展和应用进行综述,以期为未来的临床诊断提供新思路和依据。Hepatic fibrosis is a reparative response of the liver following chronic liver injury.The non-invasive assessment and staging of hepatic fibrosis are of great importance in evaluating the condition of patients with chronic liver disease,while precise quantification analysis of hepatic fibrosis is critical in assessing the severity of cirrhosis,measuring the efficacy of innovative therapies,and determining appropriate treatment methods,which have profound implications for patient prognosis.Traditionally,hepatic fibrosis staging has relied on invasive liver biopsy,but this method is limited by its invasiveness,susceptible to potential complications,and sampling errors arising from uneven lesion distribution.Non-invasive imaging techniques,characterized by high sensitivity,comprehensive assessment,and quantification capabilities,have become effective tools for evaluating hepatic fibrosis,nuclear medicine molecular imaging can directly depict and quantify metabolic changes following probe-target binding at the molecular level,allowing for the quantification of the pathophysiological process of hepatic fibrosis.The authors review the recent advancements and applications of nuclear medicine molecular probes in hepatic fibrosis research,with the goal of offering novel perspectives and evidence for future clinical diagnosis.

关 键 词：肝纤维化 分子显像 放射性核素显像 分子探针 体层摄影术 发射型计算机 单光子 正电子发射断层摄影术 

分 类 号：R817.4[医药卫生—影像医学与核医学] R575.2[医药卫生—放射医学]