Lime and orange essential oils and D-limonene as a potential COVID-19 inhibitor:Computational,in chemico,and cytotoxicity analysis  

作　　者：Aldrey Nathalia Ribeiro Correa Patrícia Weimer Rochele Cassanta Rossi Jessica Fernanda Hoffmann Letícia Scherer Koester Edna Sayuri Suyenaga Cristiano Dietrich Ferreira 

机构地区：[1]Instituto Tecnologico em Alimentos para Saúde,Universidade do Vale do Rio dos Sinos,93022-750,Sao Leopoldo,RS,Brazil [2]Programa de Pos-Graduaçao em Ciencias Farmacˆeuticas,Universidade Federal do Rio Grande do Sul,90610-000,Porto Alegre,RS,Brazil [3]Programa de Pos-Graduaçao em Toxicologia e Analises Toxicologicas,Universidade Feevale,93352-000,Novo Hamburgo,RS,Brazil

出　　处：《Food Bioscience》2023年第1期1151-1158,共8页食品生物科学（英文）

基　　金：financed in part by Conselho Nacional de Desenvol-vimento Científico e Tecnologico(CNPq)-Finance code 316360/2021-0.

摘　　要：The COVID-19 pandemic has substantially impacted the world health systems,causing public health concerns,and the search for new compounds with antiviral activity is of extreme interest.Natural molecules with bioactive potential are a trend,with essential oils(Eos)being the focus of recent studies.Thus,this study evaluates in chemico the D-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of D-limonene and lime and orange EOs with a high content of D-limonene.The EOs were extracted and characterized,and the in chemico computational analysis for the determination as a potential anti-SARS-CoV-2 was performed with D-limonene,the major compound in EOs.The cytotoxicity analysis of EOs and Dlimonene was carried out with MRC-5 and HaCaT,and the preliminary safety profile was also evaluated by the HET-CAM assay.D-limonene was suggested as a promising compound for anti-SARS-CoV-2 research,since the molecule does not provide mutagenic and cytotoxic fragments,and does not have irritating potential when diluted,in addition to having favorable pharmacokinetic characteristics,through in chemico analysis.Collectively,the results reveal the antiviral potential of lime and orange EOs,as well as their major compound.In this sense,further studies should be conducted to understand the antiviral mechanisms.

关 键 词：Essential oils D-LIMONENE anti-Sars-CoV-2 COVID-19 

分 类 号：O62[理学—有机化学]