Effect of chlorogenic acid on lipid metabolism in 3T3-L1 cells induced by oxidative stress  

作　　者：Libo Liu Chenyi Zhang Min Zhai Tianshu Yu Mengqi Pei Peng Du Aili Li Jiayi Yan Chun Li Guofang Zhang 

机构地区：[1]Key Laboratory of Dairy Science,College of Food Science,Northeast Agricultural University,Harbin,150030,China [2]National Dairy Engineering Technology Research Center,Harbin,150028,China [3]Heilongjiang Green Food Science Research Institute,Harbin,150028,China

出　　处：《Food Bioscience》2023年第1期1170-1179,共10页食品生物科学（英文）

基　　金：funded by the Distinguished Young Foundation of Heilongjiang Province of China(JQ2020C006);Academic Backbone Plan of Northeast Agricultural University(54916912);Key Project of National Dairy Innovation Research Center of Inner Mongolia(2021-National Dairy Innovation Research Center-8);Characteristic Probiotics and New Fermented Food Team in Northeast Agricultural University(54940912).

摘　　要：Chlorogenic acid(CGA),a phenolic acid compound found in a variety of natural plants,has strong antioxidant capacity.In this study,we aimed to investigate the effects of CGA on differentiation and lipid metabolism of 3T3-L1 cells,as well as its protective effect against cellular oxidative stress induced by H_(2)O_(2).We found that CGA can reduce the accumulation of intracellular ROS and attenuate the production of inflammatory cytokines TNF-αunder oxidative stress.CGA treatment significantly inhibited preadipocytes differentiation and lipid accumulation in 3T3-L1 cells.Our results suggest that CGA may regulate lipid metabolism by reducing the expression of differentiation-related genes and inhibiting triacylglyceride synthesis.The findings of this study support CGA as a potential therapeutic agent for obesity.The effects of CGA and its metabolites in vivo should be investigated to further support its application in functional foods.

关 键 词：ANTIOXIDANTS Cell differentiation Chlorogenic acid Lipid metabolism Oxidative stress 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]