不同剂量氨甲环酸对膝关节置换术患者术后影响的分析研究  

Analysis of the Effect of Different Doses of Tranexamic Acid on Patients Undergoing Knee Arthroplasty

作　　者：庄冠军 张飞 章杰勇 ZHUANG Guanjun;ZHANG Fei;ZHANG Jieyong(Department of Orthopedics,Shuyang Guangji Hospital,Suqian 223800,China)

机构地区：[1]江苏省沭阳广济医院骨科,江苏宿迁223800

出　　处：《中国伤残医学》2024年第18期37-39,48,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:对比静脉滴注10 mg/kg及20 mg/kg氨甲环酸对膝关节置换术患者术后产生的影响差异。方法:选取2022年3月-2023年12月沭阳广济医院收治的122例经膝关节置换术治疗的患者为研究对象,将其随机分为研究组和对照组,各61例。对照组静脉滴注氨甲环酸的剂量为10 mg/kg,研究组静脉滴注氨甲环酸的剂量为20 mg/kg。比较两组膝关节康复情况、血红蛋白水平、疼痛程度及膝关节功能。结果:研究组的膝关节康复优良率为91.80%,高于对照组的72.13%,差异有统计学意义(P<0.05)。术后1个月,研究组的血红蛋白水平、疼痛数字评分法评分均低于对照组,Lysholm膝关节评分高于对照组,差异均有统计学意义(P<0.05)。结论:20 mg/kg剂量的氨甲环酸能更有效地减轻患者疼痛程度、降低血红蛋白水平并改善其膝关节功能,利于患者的术后康复。Objective:To compare the effects of intravenous Tranexamic Acid(10 mg/kg and 20 mg/kg)on patients undergoing knee replacement surgery.Methods:A total of 122 patients treated by knee arthroplasty in Shuyang Guangji Hospital from March 2022 to December 2023 were selected as the research objects.They were divided into a study group and a control group randomly,with 61 cases in each group.The dosage of intravenous Tranexamic Acid was 10 mg/kg in the control group and 20 mg/kg in the study group.Knee rehabilitation,hemoglobin level,pain degree and knee function were compared between the two groups.Results:The excellent and good rate of knee rehabilitation in the study group was 91.80%,which was higher than 72.13%in the control group,the difference was statistically significant(P<0.05).One month after surgery,the hemoglobin level and pain number score of the study group were lower than those of the control group,the knee joint score of Lysholm was higher than that of the control group,with statistical significance(P<0.05).Conclusion:Tranatemocyclic Acid dose of 20 mg/kg can more effectively reduce pain,reduce hemoglobin level and improve knee joint function,which is conducive to postoperative rehabilitation of patients.

关 键 词：膝关节置换术 氨甲环酸 术后康复 膝关节功能 疼痛 

分 类 号：R687.3[医药卫生—骨科学]