血清淀粉样蛋白A在耐多药肺结核感染患者临床诊断中的应用研究  

Application of Serum Amyloid A in the Clinical Diagnosis of Multidrug-resistant Pulmonary Tuberculosis Patients

作　　者：何岚 张宇 曾忠 HE Lan;ZHANG Yu;ZENG Zhong(Department of Tuberculosis,The Fifth People’s Hospital of Ganzhou,Ganzhou 341000,China;Department of Pharmacy,The Fifth People’s Hospital of Ganzhou,Ganzhou 341000,China)

机构地区：[1]江西省赣州市第五人民医院结核科,江西赣州341000 [2]江西省赣州市第五人民医院药剂科,江西赣州341000

出　　处：《中国伤残医学》2024年第18期54-57,61,共5页Chinese Journal of Trauma and Disability Medicine

基　　金：赣州市指导性科技计划项目(GZ2020ZSF303)。

摘　　要：目的:研究血清淀粉样蛋白A(SAA)在耐多药肺结核感染患者临床诊断中的应用价值。方法:选择2021年7月-2022年7月赣州市第五人民医院收治的30例耐多药肺结核感染患者纳入研究组,同期30例其他细菌感染患者纳入对照组。两组均进行SAA检测,记录检测数据,分析探究SAA在耐多药肺结核感染中临床诊断价值。结果:研究组SAA水平高于对照组,差异有统计学意义(P<0.05)。Logistic回归分析显示,SAA与耐多药肺结核感染有关(OR>1,P<0.05)。ROC曲线图显示,SAA诊断耐多药肺结核感染的AUC为0.838,截点值取62.430 ng/mL时,可获得最佳诊断价值。30例耐多药结核患者,经治疗后不良治疗转归11例,成功治疗19例,不良治疗转归患者血清SAA水平高于成功治疗患者(P<0.05)。经Logistic回归分析,结果显示,SAA与耐多药肺结核感染不良治疗转归有关(OR>1,P<0.05)。结论:SAA在耐多药肺结核感染患者中具有较高的临床诊断价值,可作为潜在的诊断标志物,通过检测SAA的水平可更早地发现耐多药肺结核感染患者,有助于及时采取相关治疗措施。Objective:To study the clinical value of serum amyloid A(SAA)in the diagnosis of multidrug resistant pulmonary tuberculosis.Methods:Thirty patients with MDR-TB infection admitted to Ganzhou Fifth People’s Hospital from July 2021 to July 2022 were selected as research objects to be included in the study group,and 30 patients with other bacterial infections were selected as control group during the same period.SAA detection was performed in both groups,the detection data were recorded,and the clinical diagnostic value of SAA in MDR-TB infection was analyzed and explored.Results:The level of SAA in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that SAA was associated with MDR-TB infection(OR>1,P<0.05).The ROC curve showed that the AUC of SAA in the diagnosis of MDR-TB infection was 0.838,and when the cut-off point was 62.430ng/mL,the best diagnostic value could be obtained.Among the 30 MDRTB patients,11 cases had adverse treatment and 19 cases were successfully treated.The serum SAA level in the patients with adverse treatment was higher than that in the patients with successful treatment(P<0.05).Logistic regression analysis showed that SAA was associated with adverse treatment outcomes of MDR-TB infection(OR>1,P<0.05).Conclusion:SAA has high clinical diagnostic value in patients with MDR-TB infection,and can be used as a potential diagnostic marker.By detecting the level of SAA,patients with MDR-TB infection can be found earlier,which is helpful to take relevant treatment measures in time.

关 键 词：耐多药肺结核感染 血清淀粉样蛋白A 诊断价值 诊断标志物 Logistic回归 灵敏度 特异度 截断值 

分 类 号：R521[医药卫生—内科学]