1例艾沙康唑及伏立康唑导致患者药物性水肿的病例分析  

Case analysis of a patient with isavuconazole-and voriconazole-induced edema

作　　者：刘泽茹 葛继文 魏田田 蒋胜华[1] Liu Zeru;Ge Jiwen;Wei Tiantian;Jiang Shenghua(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Jining Medical University,Jining 272029,China;Department of Pharmacy,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院附属医院呼吸与危重症医学科,山东济宁272029 [2]济宁医学院附属医院药剂科,山东济宁272029

出　　处：《实用药物与临床》2024年第12期936-939,共4页Practical Pharmacy and Clinical Remedies

基　　金：济宁医学院附属医院“苗圃”科研计划(MP-MS-2023-16);济宁市重点研发计划(2023YXNS067)。

摘　　要：1例82岁男性患者,诊断为侵袭性肺毛霉菌病。患者服用硫酸艾沙康唑胶囊4 d后出现双上肢中度凹陷性水肿,左侧手背肿胀性红斑,双下肢轻度凹陷性水肿。6个月后,患者再次因疾病加重就诊,诊断为肺曲霉菌病。患者服用伏立康唑片7 d后出现双上肢中度凹陷性水肿,左上肢水肿更显著,左手背可见水泡,双下肢轻度凹陷性水肿。排除其他药物作用后考虑水肿与艾沙康唑、伏立康唑有关,给予利尿治疗后水肿可消退。停用艾沙康唑后未再出现水肿。随访至今,患者应用伏立康唑及利尿药物未再出现水肿。A 82-year-old male patient was diagnosed with invasive mucormycosis.The patient developed moderate pitting edema in both upper limbs,edematous erythematous plaques on the back of the left hand,and mild pitting edema in both lower limbs after taking isavuconazole for 4 d.After 6 months,the patient was hospitalized due to worsening disease and was diagnosed with invasive aspergillosis.After taking voriconazole for 7d,the patient developed moderate pitting edema in both upper limbs,especially in the left upper limb,blisters visible on the back of the left hand,and mild pitting edema in both lower limbs.After the exclusion of other drugs,it was considered that edema was related to isavuconazole and voriconazole;the edema could disappear after diuretic therapy,and there was no further edema after withdrawal of isavuconazole.The patient has not experienced edema again after using voriconazole and diuretics during follow-up.

关 键 词：艾沙康唑 伏立康唑 药物性水肿 

分 类 号：R969[医药卫生—药理学]