纳米技术的药物递送在急性肾损伤动物模型实验中的研究进展  

Research progress of drug delivery using nanotechnology for acute kidney injury in animal models

作　　者：杨茹楠 王蕊花[2] Yang Runan;Wang Ruihua(First Clinical College,Shanxi Medical University,Taiyuan 030000,China;Department of Nephrology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030000 [2]山西医科大学第一医院肾内科,山西太原030001

出　　处：《实用药物与临床》2024年第12期939-942,共4页Practical Pharmacy and Clinical Remedies

摘　　要：急性肾损伤(AKI)是一组临床综合征,表现为短时间内肾功能急剧下降,体内代谢废物潴留,水、电解质和酸碱平衡紊乱。目前治疗AKI的有效方法少,许多治疗药物因为生物利用度差、在肾脏停留时间短、不良反应多等原因治疗效果差。纳米技术在医学领域的快速发展为提高药物的生物利用度、精准递送药物创造了条件。目前纳米技术在临床研究方面尚不成熟,本文综述了各种纳米技术的药物递送系统(如聚合物纳米系统、无机纳米系统、脂质纳米系统、水凝胶和细胞外囊泡)在AKI动物模型中治疗的研究现状。Acute kidney injury(AKI)is a clinical syndrome characterized by a rapid decline in kidney function over a short period,leading to the retention of metabolic waste products,disturbances in water,electrolyte,and acid-base balance.Currently,there are few effective treatments for AKI,and many therapeutic drugs have poor therapeutic effects due to poor bioavailability,short residence time in kidney,and significant adverse effects.The rapid development of nanotechnology in the medical field has provided opportunities to improve the bioavailability of drugs and enable precise drug delivery.At present,nanotechnology is not yet mature in clinical research.This paper summarizes the research status of various nanotechnology drug delivery systems(such as polymer nanosystems,inorganic nanosystems,lipid nanosystems,hydrogels,and extracellular vesicles)in the treatment of AKI animal models.

关 键 词：急性肾损伤 纳米技术 药物递送 氧化应激 

分 类 号：R692[医药卫生—泌尿科学] R-332[医药卫生—外科学]