白虎加桂枝汤治疗急性痛风性关节炎的研究进展  

Research Progress on the Treatment of Acute Gouty Arthritis with Baihu plus Guizhi Decoction

作　　者：付晓晖 王玲[2] 莫成荣[2] FU Xiaohui;WANG Ling;MO Chengrong(Liaoning University of Traditional Chinese Medicine First Clinical College,Shenyang 110085,China;不详)

机构地区：[1]辽宁中医药大学第一临床学院,辽宁沈阳110085 [2]辽宁中医药大学附属医院风湿免疫科,辽宁沈阳110032

出　　处：《中国医学创新》2024年第36期180-185,共6页Medical Innovation of China

基　　金：辽宁省名老中医工作室项目(辽中医药综合字[2021]32号)。

摘　　要：痛风是一种合成过多尿酸的嘌呤代谢紊乱疾病,随着现代生活方式的发展和改变,痛风患病率逐年上升。白虎加桂枝汤是中医临床常用方剂,古往今来常用于治疗急性痛风性关节炎。药理学研究表明白虎加桂枝汤通过多通路、多靶点抑制炎小体,发挥抗炎作用,改善实验室指标,有效缓解临床症状。同时,本方适用于存在西药选择有限及不良反应较多等问题时,临床也常用白虎加桂枝汤加减及白虎加桂枝汤联合西药增强治疗效果。本文从中医和西医分别探讨白虎加桂枝汤作用机制,总结白虎加桂枝汤临床治疗急性痛风性关节炎的研究进展。Gout is a purine metabolism disorder caused by excessive synthesis of uric acid.With the development and changes in modern lifestyles,the incidence of gout has been increasing year by year.Baihu plus Guizhi Decoction is a commonly used traditional Chinese medicine formula in clinical practice,which has been used throughout history to treat acute gouty arthritis.Pharmacological studies have shown that Baihu plus Guizhi Decoction inhibits inflammasomes through multiple pathways and targets,exerts anti-inflammatory effects,improves laboratory indicators,and effectively alleviates clinical symptoms.At the same time,this formula is suitable for situations where there are limited choices of western medicine and many adverse reactions.In clinical practice,it is also commonly used to modified Baihu plus Guizhi Decoction and to enhance the therapeutic effect of Baihu plus Guizhi Decoction combined with western medicine.This article explores the mechanism of action of Baihu plus Guizhi Decoction from both traditional Chinese medicine and western medicine,and summarizes the research progress of Baihu plus Guizhi Decoction in the clinical treatment of acute gouty arthritis.

关 键 词：急性痛风性关节炎 白虎加桂枝汤 中医 作用机制 

分 类 号：R259[医药卫生—中西医结合]