基于数据挖掘探讨中医治疗酒精性肝硬化的用药规律  

Exploring the medication patterns in traditional Chinese medicine for the treatment of alcoholic cirrhosis based on data mining

作　　者：杨雯敏 钟欣 彭蓝芬 胡锐 周小舟[1,2] YANG Wen-min;ZHONG Xin;PENG Lan-fen;ZHOU Xiao-zhou(The fourth Clinical Medical College of Guangzhou University of Chinese Medicine(Shenzhen Guangdong,518033),China.)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院国家临床肝病(中医)重点专科 [3]澳门科技大学中医药学院,中国

出　　处：《中西医结合肝病杂志》2024年第12期1107-1112,共6页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家自然科学基金项目(No.82374531,82205209);深圳市科技计划项目(No.JCYJ20210324120405015);广东省中医药局项目(No.20231302)。

摘　　要：目的:本研究基于数据挖掘和复杂网络分析系统,探讨中医药治疗酒精性肝硬化的用药规律。方法:检索CNKI、SinoMed、PubMed、Embase、Medline、Cochrane、维普数据库(VIP)和万方数据库(WanFang),筛选建库至2023年10月中药复方治疗酒精性肝硬化(AC)的全部临床文献,对药物频次、归经及药物关联规则等进行统计分析。结果:共纳入文献103篇,涉及中药186味,核心药物5味。中药治疗AC以四气以微寒、温、平为主;五味以甘、苦、辛味为主,归经以归脾经、肝经为多,常用药对配伍规律9条,核心处方为茯苓、白术、丹参、黄芪、柴胡。结论:这些规律表明中医治疗酒精性肝硬化把握肝郁脾虚水停、正虚邪实的核心病机,以扶脾调肝为核心治疗理念,综合运用益气扶正、健脾利湿、条达肝气等治法。网络药理学分析表明核心处方可能通过抑制酒精对细胞凋亡、氧化应激及抗炎通路的激活,从而达到抗肝脏炎症、改善血液流变学及血流动力学、保护血管等、抗肝纤维化等作用。Objective:Data mining and complex network analysis systems was used to identify and summarize the patterns of Traditional Chinese Medicine prescriptions for the treatment of alcoholic cirrhosis.Methods:Eight databases including CNKI,SinoMed,PubMed,Embase,Medline,Cochrane,VIP and WanFang were screened out to retrieve all the clinical trials of TCM compound prescriptions in the treatment of alcoholic cirrhosis(AC)from the establishment of database to October 2023,and then statistically analyzed the drug frequency,attribution,and drug association rules.Results:A total of 103 studies were included,involving 186 traditional Chinese medicine(TCM)herbs,with 5 core herbs identified.The treatment of AC with TCM primarily utilizes the Four Natures,focusing on mild cold,warmth,and neutrality.The Five Flavors are mainly sweet,bitter,and pungent,while the meridian tropism predominantly targets the spleen and liver meridians.Nine main compatibility patterns of commonly used herb pairs were identified,with the core formula consisting of Poria,Atractylodes,Salvia miltiorrhiza,Astragalus,and Bupleurum.Conclusion:The findings suggest that TCM treatment for alcoholic cirrhosis focuses on addressing the core pathogenesis of liver qi stagnation,spleen deficiency,water retention,and the imbalance between deficiency and excess.The central therapeutic approach emphasizes strengthening the spleen and regulating the liver,integrating strategies such as tonifying qi,supporting the body's upright energy,strengthening the spleen,resolving dampness,and promoting liver qi circulation.Network pharmacology analysis indicates that the core prescription may exert its effects by inhibiting alcohol-induced activation of apoptotic,oxidative stress,and inflammatory pathways.This results in reduced liver inflammation,improved blood rheology and hemodynamics,vascular protection,and the prevention of liver fibrosis.

关 键 词：数据挖掘 酒精性肝硬化 中医药 用药规律 网络药理学 

分 类 号：R259[医药卫生—中西医结合]