Can Benzimidazole Resistance Undermine the Philippines’Success in Controlling and Eliminating Soil-Transmitted Helminth Infections?A Mini-Review  

作　　者：Jan Clyden B Tenorio Vicente Y.Belizario Jr Luis Fernando Viana Furtado Sutas Suttiprapa 

机构地区：[1]Department of Tropical Medicine,Faculty of Medicine,Khon Kaen University,Khon Kaen,Thailand [2]WHO Collaborating Center for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease),Tropical Disease Research Center,Khon Kaen University,Khon Kaen,Thailand [3]Department of Veterinary Paraclinical Sciences,College of Veterinary Medicine,University of Southern Mindanao,Kabacan,Cotabato,Philippines [4]Department of Parasitology,College of Public Health,University of the Philippines,Manila,Philippines [5]Neglected Tropical Diseases Study Group,National Institutes of Health,University of the Philippines,Manila,Philippines [6]Department of Clinical and Toxicological Analysis,Federal University of Minas Gerais,Belo Horizonte,Brazil

出　　处：《Infectious Microbes & Diseases》2024年第4期163-169,共7页感染微生物与疾病（英文）

基　　金：supported by the Postgraduate Scholarship for International Students of the Faculty of Medicine,Khon Kaen University(No.2577/2019)to JCBT and the Fundamental Fund of Khon Kaen University and the National Science,Research,and Innovation Fund to SS.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.

摘　　要：Soil-transmitted helminth(STH)infections remain a significant global health burden,affecting over 1.5 billion people worldwide.In the Philippines,STH infections continue to be prevalent,despite ongoing control efforts.The Integrated Helminth Control Program,whose cornerstone is the mass drug administration with benzimidazole drugs,has shown some success in reducing STH prevalence in the country.However,the persistence of infection prevalence being above the national and global targets and the potential for benzimidazole resistance have raised concerns about the long-term sustainability of current control strategies.This review examines the development of benzimidazole resistance in STH,focusing on the role of single nucleotide polymorphisms in theβ-tubulin isotype that alter the protein’s amino acid composition,thereby negatively affecting benzimidazole binding efficiency.This review discusses the epidemiology of STH infections in the Philippines,the implementation of the Integrated Helminth Control Program and the potential challenges posed by benzimidazole resistance.This review highlights the need for further research to assess the occurrence of benzimidazole resistance in Philippine STH populations and to explore alternative control strategies.Understanding the mechanisms of benzimidazole resistance and developing effective countermeasures is crucial for achieving sustainable STH control and elimination in the Philippines.

关 键 词：drug resistance neglected tropical diseases public health mass drug administration. 

分 类 号：R532[医药卫生—内科学]