Spread of Neisseria gonorrhoeae FC428 Subclone MLST ST13871  

作　　者：Hao Li Bang-Yong Zhu Quan Gan Tam Thi Nguyen Shao-Chun Chen 

机构地区：[1]Hospital for Skin Diseases,Institute of Dermatology,Chinese Academy of Medical Sciences&PekingUnion Medical College,Nanjing,China [2]National Center for STD Control,Chinese Center for Disease Control and Prevention,Nanjing,China [3]Institute of Dermatology,Guangxi Autonomous Region,Nanning,China [4]Oxford University Clinical Research Unit,Hanoi,Vietnam

出　　处：《Infectious Microbes & Diseases》2024年第4期203-205,共3页感染微生物与疾病（英文）

基　　金：supported by Fundamental Research Operations of the Central-level Public Welfare Research Institute of the Chinese Academy of Medical Sciences(2022-RW320-15);Jiangsu Provincial Medical Key Laboratory,Jiangsu Province Capability Improvement Project through Science,Technology and Education(ZDXYS202204).The funders had no role in study design,data collection or analysis,decision to publish,or preparation of the manuscript.

摘　　要：The main objective of this study was to investigate the relationship between a ceftriaxone-resistant Neisseria gonorrhoeae strain GX211022,isolated from China,and MLST ST13871 strains reported internationally.In this study,we determined the susceptibility of the N.gonorrhoeae isolate to antibiotics using the agar dilution method.Genotyping was performed through N.gonorrhoeae sequence typing for antimicrobial resistance(NG-STAR),N.gonorrhoeae multiantigen sequence typing(NG-MAST),and multilocus sequence typing(MLST).Additionally,phylogenetic analysis was conducted to explore the genetic relatedness to other MLST ST13871 strains.Isolate GX211022 was identified to possess penA allele 60.001 with a ceftriaxone MIC=1 mg/L and was classified as MLST ST13871 and NG-STAR ST233.Phylogenetic analysis indicated that GX211022 was clustered with isolates from Vietnam and confirmed that all MLST ST13871 strains are a subclone of the internationally disseminated high-level ceftriaxone-resistant FC428 clone.These findings highlight abundant regional spread of MLST ST13871 in Southeast Asia.

关 键 词：Neisseria gonorrhoeae GONORRHEA FC428 subclone whole-genome sequencing ASIA 

分 类 号：R378.1[医药卫生—病原生物学]