Eosinophilic Meningitis in a Patient With Early HIV Infection,Latent Syphilis and Herpes Simplex Virus 2 Meningitis  

作　　者：Chaowen Deng Qingyan Yang Lina Li Fanfan Xing 

机构地区：[1]Department of InfectiousDiseases and Microbiology,The University of Hong Kong–Shenzhen Hospital,Shenzhen,China [2]Neuromedicine Center,The University of Hong Kong-Shenzhen Hospital,Shenzhen,China

出　　处：《Infectious Microbes & Diseases》2024年第4期210-212,共3页感染微生物与疾病（英文）

基　　金：supported by Sanming Project of Medicine in Shenzhen(SZSM201911014);the High Level-Hospital Program,Health Commission of Guangdong Province,China;The funders had no role in study design,data collection or analysis,decision to publish,or preparation of the manuscript.

摘　　要：Eosinophilic meningitis is an unusual condition,particularly in patients with HIV infection or syphilis.The detection of herpes simplex virus(HSV)-2 and HIV-1 in cerebrospinal fluid from a patient with acute eosinophilic meningitis has not been previously reported.Herein,we report a case of a 26-year-old cisgender man newly diagnosed with HIV-1 infection and latent syphilis,who presented with headache and low-grade fever.He was diagnosed with both acute eosinophilic meningitis and HSV-2 meningitis,and his condition improved after treatment with acyclovir and penicillin.The compelling case indicates that HSV-2 meningitis may manifest concurrently with acute eosinophilia meningitis in patients coinfected with HIV and Treponema pallidum.Metagenomics next-generation sequencing plays an important role in identifying and further confirming pathogens responsible for central nervous system infections.

关 键 词：eosinophilic meningitis HIV herpes simplex virus 2 SYPHILIS next-generation sequencing 

分 类 号：R512.3[医药卫生—内科学]