Chemical synthesis-based structure correction of a claimed protein-free antifreeze oligosaccharide  

作　　者：David Crich 

机构地区：[1]Departments of Pharmaceutical and Biomedical Science,and Chemistry,and Complex Carbohydrate Research Center,University of Georgia,USA

出　　处：《National Science Review》2024年第11期27-28,共2页国家科学评论（英文版）

摘　　要：Psychrophilic organisms living at sub-zero temperatures produce antifreeze proteins(AFPs)or antifreeze glycopro-teins(AFGPs)to prevent the growth of cell-membrane-and organelle-damaging ice crystals.AFPs and AFGPs function by binding to ice crystals and in doing so change their morphology and induce thermal hysteresis(TH),the lowering of the freezing point below the melting point,thereby preventing crystal growth.A 2009 report of an antifreeze xyloman-nan with an average molecular weight of 2.9 kDa from the Alaskan freeze-tolerant beetle Upis ceramboides was remarkable in that it claimed the first identification of a purely oligosaccharide-based TH-inducing substance in nature that lacked a significant protein component[1].

关 键 词：CORRECTION claimed SYNTHESIS 

分 类 号：O643.4[理学—物理化学]