致病菌诱使逆行性尿路感染的黏膜免疫发病机制及其中药药理学研究进展  

Research advances on pathogenesis of mucosal immunity and pharmacology of traditional Chinese medicine for retrograde urinary tract infection induced by pathogenic bacteria

作　　者：李宗屏 李同路 李俊[1] 龚学忠[1] LI Zongping;LI Tonglu;LI Jun;GONG Xuezhong(Department of Nephrology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院肾内科,上海200071

出　　处：《上海中医药大学学报》2024年第6期92-100,共9页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82074387,81873280);上海市科委医学创新研究专项项目(20Y21902200);上海市卫健委“实施重大疑难疾病中西医协同诊疗示范工作”三年行动计划(ZY[2021-2023]-0207-01)。

摘　　要：致病菌入侵泌尿道诱使尿路感染的过程中,黏膜免疫调控起着至关重要的作用。黏膜屏障反复受损、黏膜相关恒定T细胞的功能障碍、致病菌诱导的免疫应答及免疫逃逸诱使了尿路感染的反复发生。尿路感染作为一种易复发且难治性疾病,单纯性抗感染治疗的作用有限。经过文献检索发现,很多中药的有效成分可针对性地对其发挥药理作用,在体内外均显示出良好的抗炎、免疫调节作用。对尿路感染的黏膜免疫机制予以综述,并筛选出防治尿路感染药理作用明确的中药及其有效成分,总结其有效成分的相关作用机制,以期为未来临床防治尿路感染提供研究思路及用药参考。Mucosal immune regulation plays a crucial role in the process of pathogenic bacteria invading urinary tract to induce urinary tract infection.Repeated impaired mucosal barrier,dysfunction of mucosal-associated invariant T cell,pathogenic bacteria-induced immune response and immune escape induce recurrent urinary tract infection.As a recurrent and refractory disease,the efficacy of simple anti-infective treatment is limited to urinary tract infection.After literature search,it was found that many active ingredients of traditional Chinese medicines can exert targeted pharmacological effect on it,showing good anti-inflammatory and immunomodulatory effects in vivo and in vitro.The purpose of this paper is to review the mucosal immune mechanism of urinary tract infection,screen out traditional Chinese medicines and active ingredients with clear pharmacological effects for the prevention and treatment of urinary tract infection,and summarize the relevant mechanisms of the active ingredients,with a view to providing research ideas and medication references for the prevention and treatment of urinary tract infection in the future.

关 键 词：尿路感染 致病菌 黏膜免疫 中药 有效成分 药理 

分 类 号：R285[医药卫生—中药学]