羟肟酸盐基树脂分离纯化^(89)Zr  

Purification of^(89)Zr by Hydroxamate-Based Resins

作　　者：王利强 杨凌云 俞小花[1] WANG Li-qiang;YANG Ling-yun;YU Xiao-hua(College of Metallurgy and Energy Engineering,Kunming University of Science and Technology,Kunming 650093,China;JYAMS PET Research and Development Limited,Nanjing 211100,China)

机构地区：[1]昆明理工大学冶金与能源工程学院,云南昆明650093 [2]南京江原安迪科正电子研究发展有限公司,江苏南京211100

出　　处：《核化学与放射化学》2024年第6期545-552,I0002,共9页Journal of Nuclear and Radiochemistry

摘　　要：回旋加速器轰击^(89)Y固体靶制备^(89)Zr过程中,靶件存在Fe、Al、Zn、Mg等微量金属杂质元素及大量未反应的^(89)Y,需要进行分离纯化才能应用于^(89)Zr放射性药物的制备。本工作研究了羟肟酸盐基树脂在HCl溶液中对Zr^(4+)、Y^(3+)、Fe^(3+)、Al^(3+)、Mg^(2+)、Zn^(2+)等金属元素的吸附性能及Zr^(4+)的洗脱条件。结果表明:羟肟酸盐基树脂在HCl中不吸附Y^(3+)、Al^(3+)、Zn^(2+)、Mg^(2+);在2.0~4.0mol/L的HCl溶液中,对Fe^(3+)吸附效果较差;在2.0~6.0mol/LHCl溶液中对于Zr^(4+)吸附效果较好;在0.05mol/L以上的草酸溶液中几乎不吸附Zr^(4+);采用羟肟酸盐基树脂柱,建立了在回旋加速器轰击后Y靶片中分离纯化^(89)Zr高效快速的方法,即在含有Zr^(4+)、Y^(3+)、Fe^(3+)、Al^(3+)、Zn^(2+)、Mg^(2+)等元素的溶液通过羟肟酸盐基树脂柱后,依次使用2.0mol/LHCl和去离子水过羟肟酸盐基树脂柱,最后用0.50mol/L草酸洗脱吸附在树脂柱上的Zr^(4+),得到纯化后的草酸锆溶液。稳定核素和^(89)Zr示踪的研究表明,采用羟肟酸盐基树脂纯化^(89)ZrCl_(4)溶液的工艺可行,羟肟酸盐基树脂可用于^(89)ZrCl_(4)溶液中Mg^(2+)、Fe^(3+)、Y^(3+)、Zn^(2+)等元素的去除。In the preparation of^(89)Zr using a cyclotron to bombard a^(89)Y solid target,trace metal impurities such as Fe,Al,Zn,and Mg,along with unreacted^(89)Y,are present.Separation and purification are necessary for application in^(89)Zr-labeled radiopharmaceuticals.This study conducted the following work:the static distribution coefficients of Zra^(+),Y^(3+),Fe^(3+),Mg^(2+),Zn^(2+)and Al^(3+)on hydroxamate-based resin were measured in hydrochloric acid and oxalic acid systems.The dynamic adsorption rates of these metal ions on the resin column were measured in hydrochloric acid.The breakthrough curves of Zr^(4+)in the hydroxamate-based resin were determined in hydrochloric acid.The elution of Zra+and Fe^(3+)from the resin using oxalic acid as an eluent was measured.The purification process conditions were validated using ZrCl_(4)simulated solution and trace amounts of^(89)Zr^(4+).The hydroxamate-based resin does not adsorb Y^(3+),A1^(3+),Zn^(2+),or Mg+in HCl.In 2.0 mol/L to 4.0 mol/L HCl solution,the adsorption of Fe^(3+)is poor,while the adsorption of Zr^(4+)is good in 2.0 mol/L to 6.0 mol/L HCl solution.The hydroxamate-based resin hardly adsorbs Zr^(4+)in oxalic acid solutions above 0.05 mol/L,and its adsorption capacity for Fe^(3+)first increases and then decreases with higher oxalic acid concentrations,reaching the strongest capacity at 0.5 mol/L.Zr^(4+)is adsorbed by the hydroxamate-based resin column in 2.0 mol/L to 6.0 mol/L HCl solution,with an adsorption rate exceeding 95%.As the HCI concentration increases to 8.0 mol/L,the adsorption rate drops to 61.42%.Y^(3+),Al^(3+),and Mg^(2+)are hardly adsorbed in 2.0 mol/L to 8.0 mol/L HCI.Fe^(3+)shows negligible adsorption in 2.0 mol/L to 4.0 mol/L HCl,but the adsorption rate increases to 15.69%at 8.0 mol/L HCl.Using 200 mg of hydroxamate-based resin meets the adsorption capacity requirements for Zr^(4+)in the purification of^(89)ZrCl_(4)solution.During Zr purification,a 0.10 mol/L to 1.00 mol/L oxalic acid solution can be chosen for elution,but it is difficult to wa

关 键 词：^(89)ZrCl_(4) 金属杂质 纯化 羟肟酸盐基树脂 

分 类 号：TL922[核科学技术—核燃料循环与材料]