人干扰素α2b雾化吸入联合孟鲁司特钠治疗小儿支气管哮喘的效果及对免疫功能、气道重塑指标的影响  

Effect of human interferonα2b inhalation combined with montelukast sodium in the treatment of infantile bronchial asthma and its influences on immune function and airway remodeling indicators

作　　者：王辉[1] 张翔武 WANG Hui;ZHANG Xiangwu(Pediatrics Department,the People's Hospital of Ziyang County,Ankang 725399;Pediatrics Department,the People's Hospital of Ganquan County,Yan'an 716100,China)

机构地区：[1]紫阳县人民医院儿科,陕西安康725399 [2]甘泉县人民医院儿科,陕西延安716100

出　　处：《临床医学研究与实践》2024年第35期90-93,共4页Clinical Research and Practice

摘　　要：目的探讨人干扰素α2b雾化吸入联合孟鲁司特钠治疗小儿支气管哮喘(BA)的效果。方法择取2021年2月至2022年12月收治的85例BA患儿为研究对象,随机将其分为对照组(42例)和观察组(43例)。对照组采用孟鲁司特钠治疗,观察组在对照组基础上增加人干扰素α2b雾化吸入治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的转化生长因子β_(1)(TGF-β_(1))、骨桥蛋白(OPN)、基质金属蛋白酶-9(MMP-9)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、呼气流量峰值(PEF)均高于对照组,差异具有统计学意义(P<0.05)。结论人干扰素α2b雾化吸入联合孟鲁司特钠治疗小儿BA效果显著,不仅能够提高患儿免疫功能,调节气道重塑指标,还能促进肺功能恢复,值得推广。Objective To investigate the effect of human interferonα2b inhalation combined with montelukast sodium in the treatment of infantile bronchial asthma(BA).Methods A total of 85 children with BA admitted from February 2021 to December 2022 were selected as the research objects and randomly divided into control group(42 cases)and observation group(43 cases).The control group was treated with montelukast sodium,and the observation group was treated with human interferonα2b inhalation on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of transforming growth factor-β_(1)(TGF-β_(1)),osteopontin(OPN)and matrix metalloproteinase 9(MMP-9)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and peak expiratory flow(PEF)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Human interferonα2b inhalation combined with montelukast sodium in the treatment of infantile BA has a significant effect.It can not only improve the immune function of children,regulate airway remodeling indicators,but also promote the recovery of lung function,which is worthy of promotion.

关 键 词：孟鲁司特钠 人干扰素α2b 雾化吸入 支气管哮喘 免疫功能 气道重塑 

分 类 号：R256.12[医药卫生—中医内科学]