GFAP、HIF-1α表达与溃疡性结肠炎患者疾病活动度、肠道菌群的相关性分析  

Correlation analysis of GFAP and HIF-1αexpression with disease activity and gut microbiota in patients with ulcerative colitis

作　　者：杨聪艳 白薇 范芬芬 YANG Congyan;BAI Wei;FAN Fenfen(Xi'an Daxing Hospital,Xi'an 710016,China)

机构地区：[1]西安大兴医院,陕西西安710016

出　　处：《临床医学研究与实践》2024年第35期114-117,共4页Clinical Research and Practice

摘　　要：目的分析胶质原纤维酸性蛋白(GFAP)、低氧诱导因子-1α(HIF-1α)表达与溃疡性结肠炎患者疾病活动度、肠道菌群的相关性。方法选取2022年1月至2023年1月我院收治的80例溃疡性结肠炎患者作为观察组,另选取同期80名体检正常者作为对照组。以Mayo评分评估观察组的疾病活动度,将其分为轻度活动度、中度活动度、重度活动度。测定并比较观察组与对照组及观察组不同疾病活动度患者的GFAP、HIF-1α水平及肠道菌群分布情况,分析GFAP、HIF-1α与肠道菌群分布情况及疾病活动度的相关性。结果观察组的GFAP、HIF-1α水平高于对照组(P<0.05)。观察组的乳杆菌、双歧杆菌、拟杆菌、丁酸梭菌少于对照组(P<0.05)。轻度活动度患者的乳杆菌、双歧杆菌、拟杆菌、丁酸梭菌多于中度活动度、重度活动度,中度活动度患者的乳杆菌、双歧杆菌、拟杆菌、丁酸梭菌多于重度活动度(P<0.05)。轻度活动度患者的GFAP、HIF-1α水平低于中度活动度、重度活动度,中度活动度患者的GFAP、HIF-1α水平低于重度活动度(P<0.05)。Pearson相关性分析结果显示,GFAP、HIF-1α与乳杆菌、双歧杆菌、拟杆菌、丁酸梭菌呈负相关(P<0.05);Spearman秩相关分析结果显示,GFAP、HIF-1α与疾病活动度呈正相关(P<0.05)。结论GFAP、HIF-1α参与溃疡性结肠炎的发生发展过程,其与疾病活动度呈正相关,与肠道有益菌群呈负相关。Objective To analyze the correlation of glial fibrillary acidic protein(GFAP)and hypoxia inducible factor-1α(HIF-1α)expression with disease activity and gut microbiota in patients with ulcerative colitis.Methods A total of 80 patients with ulcerative colitis admitted in our hospital from January 2022 to January 2023 were selected as observation group,and 80 patients with normal physical examination during the same period were selected as control group.The disease activity of the observation group was evaluated by Mayo score,which was divided into mild activity,moderate activity and severe activity.The levels of GFAP and HIF-1αand the distribution of gut microbiota in the observation group and the control group and the observation group with different disease activity were measured and compared,and the correlation between GFAP and HIF-1αand the distribution of gut microbiota and disease activity was analyzed.Results The levels of GFAP and HIF-1αin the observation group were higher than those in the control group(P<0.05).The Lactobacillus,Bifidobacterium,Bacteroides and Clostridium butyricum in the observation group were less than those in the control group(P<0.05).The Lactobacillus,Bifidobacterium,Bacteroides and Clostridium butyricum in patients with mild activity were more than those in patients with moderate activity and severe activity,and the Lactobacillus,Bifidobacterium,Bacteroides and Clostridium butyricum in patients with moderate activity were more than those in patients with severe activity(P<0.05).The levels of GFAP and HIF-1αin patients with mild activity were lower than those in patients with moderate activity and severe activity,and the levels of GFAP and HIF-1αin patients with moderate activity were lower than those in patients with severe activity(P<0.05).Pearson correlation analysis results showed that GFAP and HIF-1αwere negatively correlated with Lactobacillus,Bifidobacterium,Bacteroides and Clostridium butyricum(P<0.05);Spearman rank correlation analysis results showed that GFAP and HI

关 键 词：溃疡性结肠炎 胶质纤维酸性蛋白 低氧诱导因子-1Α 疾病活动度 肠道菌群 

分 类 号：R574.62[医药卫生—消化系统]