血栓弹力图参数指导输血治疗对高危妊娠产后大出血产妇血小板活化功能、纤溶功能的影响  

Effects of thrombelastogram parameters guided blood transfusion therapy on platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage

作　　者：杨珍珍[1] 刘莹[1] 张骏强 刘小艳[1] 曹婉莹 安莹花[1] 梁会娟[1] YANG Zhenzhen;LIU Ying;ZHANG Junqiang;LIU Xiaoyan;CAO Wanying;AN Yinghua;LIANG Huijuan(Baoji Maternal and Child Health Care Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市妇幼保健院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2024年第35期138-141,共4页Clinical Research and Practice

摘　　要：目的探讨血栓弹力图参数指导输血治疗对高危妊娠产后大出血产妇血小板活化功能、纤溶功能的影响。方法选取2021年1月至2023年1月我院收治的80例高危妊娠产后大出血产妇为研究对象,根据输血指导方式不同将其分为对照组(40例,以常规方式指导输血治疗)和观察组(40例,以血栓弹力图参数指导输血治疗)。比较两组的治疗效果。结果治疗后,观察组的凝血反应时间(R)、血凝块形成时间(K)短于对照组,α角、血凝块最大强度(MA)大于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血小板α颗粒膜蛋白-140(GMP-140)水平及血小板最大聚集率(MAR)高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的纤维蛋白降解产物(FDP)、D-二聚体(D-D)水平高于对照组,蛋白C(PC)水平低于对照组,差异具有统计学意义(P<0.05)。结论血栓弹力图参数指导输血治疗能更有效地改善高危妊娠产后大出血产妇血小板活化功能、纤溶功能,值得推广。Objective To explore the effects of thrombelastogram parameters guided blood transfusion therapy on platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage.Methods A total of 80 high-risk pregnant women with postpartum hemorrhage admitted in our hospital from January 2021 to January 2023 were selected as the research objects.According to different blood transfusion guidance methods,the pregnant women were divided into control group(40 cases,guided by routine blood transfusion treatment)and observation group(40 cases,guided by thrombelastogram parameters).The therapeutic effects of the two groups were compared.Results After treatment,the reaction time(R)and kinetics time(K)in the observation group were shorter than those in the control group,and theαangle and maximum amplitude(MA)were greater than those in the control group,and the differences were statistically significant(P<0.05).After treatment,α-granule membrane protein-140(GMP-140)level and platelet maximum aggregation rate(MAR)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of fibrinogen degradation products(FDP)and D-dimers(D-D)in the observation group were higher than those in the control group,and the level of protein C(PC)was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Thrombelastogram parameters guided blood transfusion therapy can more effectively improve platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage,which is worthy of promotion.

关 键 词：血栓弹力图参数 输血 高危妊娠 产后大出血 血小板活化功能 纤溶功能 

分 类 号：R714.461[医药卫生—妇产科学]