依那普利联合阿托伐他汀对原发性高血压合并高脂血症患者颈动脉IMT、血液流变学及脂代谢的影响  

Effects of Enalapril Combined with Atorvastatin on Carotid IMT,Hemorheology and Lipid Metabolism in Patients with Essential Hypertension Combined with Hyperlipidemia

作　　者：曾怡春 李俊 ZENG Yichun;LI Jun(Department of Emergency,Fuzhou Maternal and Child Health Hospital,Fuzhou 344000,China)

机构地区：[1]抚州市妇幼保健院急诊科,江西抚州344000

出　　处：《中国医学创新》2024年第35期6-10,共5页Medical Innovation of China

摘　　要：目的:分析依那普利联合阿托伐他汀对原发性高血压合并高脂血症患者颈动脉内-中膜厚度(IMT)、血液流变学及脂代谢的影响。方法:选择抚州市妇幼保健院2022年3月—2024年3月收治的原发性高血压合并高脂血症患者86例,使用随机数字表法将其分为辛伐他汀组和阿托伐他汀组,各43例。辛伐他汀组给予依那普利联合辛伐他汀治疗,阿托伐他汀组给予依那普利联合阿托伐他汀治疗,两组均治疗2个月。比较两组治疗前后血压、颈动脉IMT、血液流变学指标、脂代谢[高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]及不良反应。结果:治疗后,阿托伐他汀组收缩压、舒张压均低于辛伐他汀组,颈动脉IMT小于辛伐他汀组,差异均有统计学意义(P<0.05)。治疗后,阿托伐他汀组红细胞聚集指数、全血高切黏度、血浆黏度、全血低切黏度均低于辛伐他汀组,差异均有统计学意义(P<0.05)。治疗后,阿托伐他汀组TC、TG、LDL-C均低于辛伐他汀组,HDL-C高于辛伐他汀组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:依那普利联合阿托伐他汀治疗原发性高血压合并高脂血症可显著降低患者血压、血液流变学指标,改善脂代谢和颈动脉IMT,且安全性良好。Objective:To analyze the effects of Enalapril combined with Atorvastatin on carotid intimamedia thickness(IMT),hemorheology and lipid metabolism in patients with essential hypertension combined with hyperlipidemia.Method:A total of 86 patients with essential hypertension combined with hyperlipidemia admitted to Fuzhou Maternal and Child Health Hospital from March 2022 to March 2024 were selected and divided into Simvastatin group and Atorvastatin group by random number table method,with 43 cases in each group.Simvastatin group was treated with Enalapril combined with Simvastatin,Atorvastatin group was treated with Enalapril combined with Atorvastatin,and both groups were treated for 2 months.Blood pressure,carotid IMT,hemorheology indexes,lipid metabolism[high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),triglyceride(TG),lowdensity lipoprotein cholesterol(LDL-C)]before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the systolic blood pressure and diastolic blood pressure in Atorvastatin group were lower than those in Simvastatin group,and carotid IMT was lower than that in Simvastatin group,the differences were statistically significant(P<0.05).After treatment,the red blood cell aggregation index,whole blood high shear viscosity,plasma viscosity and whole blood low shear viscosity in Atorvastatin group were lower than those in Simvastatin group,the differences were statistically significant(P<0.05).After treatment,TC,TG and LDL-C in Atorvastatin group were lower than those in Simvastatin group,and HDL-C was higher than that in Simvastatin group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Enalapril combined with Atorvastatin in the treatment of essential hypertension combined with hyperlipidemia can significantly reduce blood pressure and hemorheology indexes,improve lipid metabolism and carotid IMT,and has good safety.

关 键 词：原发性高血压 高脂血症 阿托伐他汀 依那普利 脂代谢 

分 类 号：R544.11[医药卫生—心血管疾病] R589.2[医药卫生—内科学]