经皮穴位电刺激对老年患者全髋关节置换术后认知功能及血清S100β蛋白和SIRT1水平的影响  

Effects of Transcutaneous Electrical Acupoint Stimulation on Cognitive Function and Serum S100βProtein and SIRT1 Levels in Elderly Patients after Total Hip Arthroplasty

作　　者：汪文琴[1] 徐贤亮 余奕军 夏萍萍 李琳慧 涂江南 WANG Wenqin;XU Xianliang;YU Yijun;XIA Pingping;LI Linhui;TU Jiangnan

机构地区：[1]江西中医药大学附属医院麻醉科,江西南昌330006 [2]江西中医药大学附属医院针灸一科,江西南昌330006

出　　处：《中国医学创新》2024年第35期48-52,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2022A269)。

摘　　要：目的:分析经皮穴位电刺激(TEAS)对老年患者全髋关节置换术后认知功能及血清S100β蛋白和沉默调节蛋白1(SIRT1)水平的影响。方法:选择2022年5月—2023年12月江西中医药大学附属医院收治的100例行全髋关节置换术老年患者,随机分为电刺激组和假刺激组,各50例。在麻醉诱导前,电刺激组经双侧内关、足三里穴给予电刺激;假刺激组在双侧内关、足三里各贴一电极但不接通电源。比较两组血清S100β蛋白、SIRT1水平及术后认知功能障碍(POCD)发生率。结果:术前,两组血清S100β蛋白和SIRT1水平比较,差异均无统计学意义(P>0.05);术后,电刺激组血清S100β蛋白低于假刺激组,血清SIRT1水平高于假刺激组,差异均有统计学意义(P<0.05)。术后1 d,两组POCD发生率比较,差异无统计学意义(P>0.05);术后7 d,电刺激组POCD发生率为14.0%,低于假刺激组的32.0%,差异有统计学意义(P<0.05)。结论:TEAS干预可抑制老年患者全髋关节置换术后血清S100β蛋白的升高,并提高血清SIRT1水平,还可减少POCD的发生。Objective:To investigate the effects of transcutaneous electrical acupoint stimulation(TEAS)on cognitive function and serum S100βprotein and sirtuin 1(SIRT1)levels in elderly patients after total hip arthroplasty.Method:A total of 100 elderly patients with total hip arthroplasty admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from May 2022 to December 2023 were randomly divided into electric stimulation group and false stimulation group,with 50 cases in each group.Before anesthesia induction,the electrical stimulation group was given electrical stimulation through both Neiguan and Zusanli points;in the false stimulation group,one electrode was attached to each side of Neiguan and Zusanli,but the power was not connected.The serum levels of S100βprotein and SIRT1 and the incidence of postoperative cognitive dysfunction(POCD)were compared between the two groups.Result:Before surgery,there were no significant differences in serum S100βprotein and SIRT1 levels between two groups(P>0.05).After surgery,serum S100βprotein and serum SIRT1 levels in electrical stimulation group were lower than those in false stimulation group,the differences were statistically significant(P<0.05).On the 1 d after surgery,there was no significant difference in the incidence of POCD between the two groups(P>0.05).On the 7 d after surgery,the incidence of POCD in the electrical stimulation group was 14.0%,which was lower than 32.0%in the false stimulation group,the difference was statistically significant(P<0.05).Conclusion:TEAS can inhibit the increase of serum S100βprotein and increase the level of serum SIRT1 protein after total hip replacement in elderly patients,and also decrease the occurrence of POCD.

关 键 词：老年患者 术后认知功能障碍 经皮穴位电刺激 S100Β蛋白 

分 类 号：R614[医药卫生—麻醉学]