中药提取物通过调节铁死亡在胃肠道恶性肿瘤治疗及耐药性中的研究进展  

Research Progress of Traditional Chinese Medicine Extracts in the Treatment and Drug Resistance of Gastrointestinal Malignant Tumors Through Ferroptosis

作　　者：罗经煌 王晓通[2] 黄海舸[3] LUO Jinghuang;WANG Xiaotong;HUANG Haige

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]广西壮族自治区人民医院胃肠疝肠瘘外科,广西南宁530021 [3]右江民族医学院附属医院普通外科,广西百色533000

出　　处：《中国医学创新》2024年第35期159-164,共6页Medical Innovation of China

基　　金：国家自然科学基金项目(82260468);右江民族医学院附属医院高层次人才项目(R20212602)。

摘　　要：中药提取物可以通过多种机制调节铁死亡,为肿瘤治疗提供新的策略。铁死亡是一种铁依赖性的细胞死亡形式,与肿瘤的发生、发展、治疗及耐药性密切相关。中药提取物在肿瘤治疗中的策略已引起广泛关注,中药提取物通过调节铁代谢、影响脂质代谢、发挥抗氧化作用和干预铁死亡信号通路等方式,能够促进肿瘤细胞死亡并增强对现有治疗方法的敏感性。此外,其潜在的低毒性、多样化的药理活性使其成为提高化疗敏感性和克服化疗耐药性的重要补充。因此,本文回顾了铁死亡的机制及中药提取物在胃肠道恶性肿瘤中治疗的最新进展,探讨中药提取物通过铁死亡与胃肠道恶性肿瘤耐药的关系及进一步讨论其潜在的价值,从而为临床上肿瘤耐药性治疗提供新的研究思路。Traditional Chinese medicine can regulate ferroptosis through various mechanisms and provide a new strategy for tumor treatment.Ferroptosis is a form of iron-dependent cell death,which is closely related to the occurrence,development,treatment and drug resistance of tumors.The strategies of traditional Chinese medicine extracts in tumor therapy have attracted wide attention.By regulating iron metabolism,affecting lipid metabolism,playing an antioxidant role and interfering with ferroptosis signaling pathway,traditional Chinese medicine extracts can promote tumor cell death and enhance sensitivity to existing therapies.In addition,its potential low toxicity and diverse pharmacological activities make it an important supplement to improve chemotherapy sensitivity and overcome chemotherapy resistance.Therefore,this paper reviews the mechanism of ferroptosis and the latest progress of traditional Chinese medicine extracts in the treatment of gastrointestinal malignancies,discusses the relationship between traditional Chinese medicine extracts and drug resistance of gastrointestinal malignancies through ferroptosis and further discussed its potential value,so as to provide a new research idea for the clinical treatment of tumor resistance.

关 键 词：中药提取物 铁死亡 肿瘤治疗 耐药性 

分 类 号：R273[医药卫生—中西医结合]