马来酸麦角新碱联合卡贝缩宫素预防剖宫产术后出血临床效果  

Clinical effect of the combination of ergometrine maleate and capecitabine for preventing the postpartum hemorrhage of women after cesarean section

作　　者：白洁[1] 王丽娟[1] 王宇翔 皇甫佳欣 BAI Jie;WANG Lijuan;WANG Yuxiang;HUANGFU Jiaxin(Taiyuan Hospital of Peking University First Hospital(Taiyuan Central Hospital),Taiyuan,Shanxi Province,030009;Clinical College of Hebei Medical University,Shijiazhuang,Hebei Province)

机构地区：[1]北京大学第一医院太原医院,太原市中心医院,030009 [2]河北医科大学临床学院

出　　处：《中国计划生育学杂志》2024年第12期2754-2757,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨马来酸麦角新碱联合卡贝缩宫素预防剖宫产术后出血临床效果及药物应用安全性。方法:纳入2022年1月-2024年4月本院剖宫产产妇98例,随机数字表法分为单药组(49例,采取卡贝缩宫素治疗)及联合组(49例,采取马来酸麦角新碱联合卡贝缩宫素治疗),对比两组剖宫产术后出血发生率、剖宫产术后各时间点出血量、术前1d与术后1d产妇纤维蛋白原、凝血酶时间与凝血酶原时间及血红蛋白水平、不良反应、治疗满意度,出院随访1个月,评估产妇焦虑自评量表(SAS)及抑郁自评量表(SDS)、生活质量量表评分(SF-36)情况。结果:联合组剖宫产产后出血发生率(18.4%)低于单药组(38.8%),术后2h(189.7±10.7ml)、12h(252.4±7.6ml)、24h(329.7±7.3ml)出血量均少于单药组(224.5±9.6ml、349.6±8.6ml、453.9±8.5ml),术后1d血纤维蛋白原、凝血酶时间与凝血酶原时间及血红蛋白水平指标均优于单药组,出院后1个月SAS评分(40.23±6.23分)、SDS评分(42.19±7.23分)、SF-36评分(89.62±3.16分)均优于单药组(49.65±8.52分、51.25±9.45分、84.23±2.75分)(均P<0.05);两组不良反应发生率(6.1%、4.1%)无差异(P>0.05);治疗满意率联合组(95.9%)高于单药组(81.6%)(P<0.05)。结论:马来酸麦角新碱联合卡贝缩宫素预防剖宫产术后出血临床效果良好,可改善产妇凝血功能,减少出血量,改善产妇心理状态及生活质量,治疗不良反应少,满意度较高。Objective:To investigate the clinical effect and the safety of ergotrine maleate combined with carbetin for preventing the hemorrhage of women after cesarean section.Methods:A total of 98 pregnant women who wanted cesarean section were included and were divided into control group(49 cases with the treatment of carbetocin)and study group(49 cases with the treatment of ergocline maleate and carbetocin)by random number table method from January 2022 to April 2024.The incidence of the postpartum hemorrhage and the amount of blood loss at different time point after cesarean section,the values of fibrinogen,thrombin time and prothrombin time,and hemoglobin level in ld before cesarean section and in ld after cesarean section,the adverse reactions rate,the maternal treatment satisfaction of the women were compared between the two groups.The women in the two groups were followed up for 1-month after discharge.The self-rating anxiety scale(SAS),the self-rating depression scale(SDS)and the quality of life scale(SF-36)were used to evaluate the maternal anxiety and depression.Results:The incidence of the postpartum hemorrhage(18.4%)of the women in the study group after cesarean section was significantly lowers than that(38.8%)of the women in the control group.The amount of bleeding of the women in the study group at postoperative 2h(189.7±10.7 ml),12h(252.4±7.6ml)or 24h(329.7±7.3ml)was significantly less than that(224.5±9.6 ml,349.6±8.6 ml or 453.9±8.5 ml)of the women in the control group.The values of the blood fibrinogen,thrombin time and prothrombin time,and the hemoglobin level of the women in the study group in 1 day after cesarean section were significantly better than those of the women in the control group.In 1 month after discharge,the scores of SAS(40.23±6.23 points),SDS(42.19±7.23 points)and SF-36(89.62±3.16 points)of the women in the study group were significantly better than those(49.65±8.52 points,51.25±9.45 points and 84.23±2.75 points)of the women in the control group(all P<0.05).There was no signi

关 键 词：剖宫产术 产后出血 卡贝缩宫素 马来酸麦角新碱 凝血功能 心理状态生活质量 不良反应 

分 类 号：R719.8[医药卫生—妇产科学]