寿胎四君安胎饮用于治疗PCOS合并胰岛素抵抗早期先兆流产的疗效观察  

Effect of Shoutai sijun antai decoction for treating patients with early threatened abortion and polycystic ovarian syndrome complicated with insulin resistance

作　　者：王晨亦 朱亮 游旭宇 WANG Chenyi;ZHU Liang;YOU Xuyu(Jinhua Maternal and Child Health Care Hospital,Jinhua,Zhejiang Province,321000;Jinhua Hospital Affiliated to School of Medicine,Zhejiang University)

机构地区：[1]浙江省金华市妇幼保健院,321000 [2]浙江大学医学院附属金华医院

出　　处：《中国计划生育学杂志》2024年第12期2801-2804,2810,共5页Chinese Journal of Family Planning

基　　金：金华市妇幼保健院科研培育基金(JHFB2021-2-07)。

摘　　要：目的:观察寿胎四君安胎饮治疗多囊卵巢综合征(PCOS)合并胰岛素抵抗(IR)早期先兆流产脾肾两虚证患者的有效性及对IR、性激素水平的影响。方法:选择2021年6月-2023年6月在本院就诊的PCOS合并IR早期先兆流产患者80例,随机分为对照组和观察组各40例。两组均予黄体酮注射液、地屈孕酮治疗,观察组加用寿胎四君安胎饮中药饮片口服治疗,疗程2周。观察治疗前后两组中医证候积分、血清孕酮(P)、雌二醇(E_(2))、人绒毛膜促性腺激素β(β-hCG)、空腹血糖、空腹胰岛素、IR指数(HOMA-IR)改善情况,评价疗效。结果:治疗2周后,两组中医证候积分、空腹血糖、空腹胰岛素、HOMA-IR水平均降低,观察组改善优于对照组(均P<0.05);P、E_(2)、β-hCG均升高,观察组改善优于对照组(均P<0.05)。观察组总有效率95.00%高于对照组80.00%(P<0.05)。结论:寿胎四君安胎饮联合西药孕激素黄体支持保胎疗法,可改善PCOS合并IR早期先兆流产患者临床症状,减轻IR并调节患者性激素水平,提高保胎疗效。Objective:To observe the efficacy of Shoutai sijun antai decoction for treating patients with early threatened abortion and polycystic ovarian syndrome(PCOS)complicated with insulin resistance,and to study its impacts on the insulin resistance and sex hormone levels of the patients.Methods:80 patients with early threatened abortion and PCOS complicated with insulin resistance who were treated in the hospital were selected and were randomly divided into the control group and the observation group(40 cases in each group)from June 2021 to June 2023.The patients in the two groups were treated with progesterone injection and dydrogesterone for 2 weeks,and the patients in the observation group were given Shoutai sijun antai decoction for 2 weeks additionally.The changes of the traditional Chinese medicine(TCM)syndrome score,the levels of the serum progesterone(P),estradiol(E_(2)),human chorionic gonadotropin β(β-hCG),fasting blood glucose and fasting insulin,and the homeostasis model assessment of insulin resistance(HOMA-IR)value of the patients in the two groups before and after treatment were observed.The curative effect of the patients in the two groups was evaluated.Results:2 weeks after treatment,the TCM syndrome score,the levels of the serum,fasting blood glucose and fasting insulin,and the HOMA-I value of the patients in the two groups had decreased significantly,and which of the patients in the observation group were significantly superior to those of the patients in the control group(all P<0.05).The levels of P,E and β-hCG of the patients in the two groups had increased significantly,and which of the patients in the observation group were significantly superior to those of the patients in the control group(all P<0.05).The total effective rate(95.00%)of the patients in the observation group was significantly higher than that(80.00%)of the patients in the control group(P<0.05).Conclusion:Shoutai sijun antai decoction combined with luteal support of the western medicine progesterone for treating the patients w

关 键 词：先兆流产 多囊卵巢综合征 胰岛素抵抗 寿胎四君安胎饮 地屈孕酮 黄体酮注射液 

分 类 号：R271.9[医药卫生—中西医结合]