sFlt-1/PlGF比值联合D-二聚体评估PE发生的临床价值及与不良妊娠结局关系  

Clinical value of the soluble vascular endothelial growth factor receptor-1/placental growth factor ratio combined with the D-Dimer level of pregnant women for evaluating the risk of their preeclampsia occurrence and their correlation wity adverse pregnancy outcomes

作　　者：张云 闻明[1] 余益香 王琳[1] 李晶晶 ZHANG Yun;WEN Ming;YU Yixiang;WANG Lin;LI Jingjing(The First People's Hospital of Wuhu,Wuhu,Anhui Province,241000)

机构地区：[1]安徽省芜湖市第一人民医院,241000

出　　处：《中国计划生育学杂志》2024年第12期2890-2894,共5页Chinese Journal of Family Planning

基　　金：芜湖市科技计划项目(2022cg35);2022年安徽省重点研究与开发计划项目(2022b13020002)。

摘　　要：目的:评估可溶性血管内皮生长因子受体-1(sFlt-1)/胎盘生长因子(PlGF)比值(sFlt-1/PlGF)联合D-二聚体(D-D)在子痫前期(PE)风险和妊娠结局中的临床价值。方法:选取2022年1月-2024年1月本院产科收治的90例PE孕妇(PE组)及同期产前检查正常孕妇(对照组)90例临床资料,荧光免疫法测定血清sFlt-1、PlGF水平,经凝血仪测定D-D水平,对比不同病情、不同妊娠结局PE孕妇上述指标,分析sFlt-1/PlGF联合D-D预测PE价值及其与不良妊娠结局关系。结果:PE组中轻度组、重度组血清sFlt-1、sFlt-1/PlGF和D-D均高于对照组,PlGF水平低于对照组,且对照组、轻度组、重度组血清sFlt-1、sFlt-1/PlGF、D-D依次升高,PlGF依次降低;PE组发生不良妊娠结局孕妇血清sFlt-1、sFlt-1/PlGF、D-D水平高于未发生不良妊娠结局孕妇,PlGF低于未发生不良妊娠结局孕妇(均P<0.05)。血清sFlt-1、PlGF、sFlt-1/PlGF与D-D联合预测PE的曲线下面积(0.880)、敏感度(0.84%)高于各指标单独预测(P<0.05);PE孕妇血清sFlt-1、D-D、sFlt-1/PlGF水平与不良妊娠结局呈正相关,PlGF水平与不良妊娠结局呈负相关(均P<0.05)。结论:sFlt-1、PlGF、sFlt-1/PlGF与D-D联合检测预测PE临床价值较好,且PE孕妇各指标水平与不良妊娠结局发生具有相关性。Objective:To evaluate the clinical value of soluble vascular endothelial growth factor receptor-1/placental growth factor ratio(sFlt-1/PIGF)combined with D-dimer(D-D)level of pregnant women for evaluating the risk of their preeclampsia occurrence and pregnancy outcomes.Methods:A total of 9o pregnant women with preeclampsia who were admitted to the department of obstetrics were selected in study group and 90 normal pregnant women were selected in control group from January 2022 to January 2024.The women in the study group were divided in group A(women with mild preeclampsia)and group B(women with severe preeclampsia).The serumsFlt-1 and PIGF levels of the women in the two groups were measured by fluorescence immunoassay,and the D-D level of the women in the two groups was measured by a coagulometer.The serum sFlt-1,PIGF and D-D levels of the women in the study group were compared among the women with the different preeclampsia conditions and among the women with the different pregnancy outcomes.The predictive value of the sFlt-1/PIGF ratio combined with the D-D level of the pregnant women for their preeclampsia and the correlation between the sFlt-1/PIGF ratio and the D-Dimer level of the women and their pregnancy outcomes were analyzed.Results:The levels of serum sFlt-1,sFlt-1/PIGF and D-D of the women in group A and in group B were significantly higher than those of the women in the control group,and the level of PIGF of the women in group A and in group B was significantly lower than that of the women in the control group.The serum levels of sFlt-1 and D-D,and the sFlt-1/PIGF ratio of the women in the control group,in group A and in group B had increased gradually,and the PlGF level of them had decreased gradually.In the study group,the serum levels of sFlt-1 and D-D,and sFlt-1/PIGF ratio of the women with the adverse pregnancy outcomes were significantly higher than those of the women with the normal pregnancy outcomes,and the PIGF level of the women with the adverse pregnancy outcomes was significantly lower(

关 键 词：子痫前期 可溶性血管内皮生长因子受体-1 胎盘生长因子 D-二聚体 不良妊娠结局 相关性 预测 

分 类 号：R714.244[医药卫生—妇产科学]