特发性间质性肺炎病人血清STAT3和FOXM1水平与病情程度及预后的关系研究  

Study on the relationship between serum STAT3 and FOXM1 levels,severity and prognosis in patients with idiopathic interstitial pneumonia

作　　者：王泽凤 邱勤[1] 谭建东 杨黎[2] WANG Zefeng;QIU Qin;TAN Jiandong;YANG Li(Department of Respiratory Nephrology,Sichuan Province Building Hospital,Chengdu,Sichuan 610084,China;Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China)

机构地区：[1]四川省建筑医院呼吸肾病科,四川成都610084 [2]成都医学院第一附属医院呼吸与危重医学科,四川成都610500

出　　处：《安徽医药》2025年第1期69-74,共6页Anhui Medical and Pharmaceutical Journal

基　　金：成都医学院第一附属医院科研项目国临培专项(CYFY2018GLPHX06)。

摘　　要：目的探讨特发性间质性肺炎(IIP)病人血清信号转导及转录激活因子3(STAT3)、叉头框转录因子M1(FOXM1)表达水平与其病情程度和预后的关系。方法选取2017年1月至2022年10月四川省建筑医院收治的298例IIP病人为IIP组,选取同时期该院收治的298例普通型间质性肺炎(UIP)病人为UIP组,另选取同时期在该院体检的280例健康人员为对照组。采用酶联免疫吸附测定(ELISA)检测血清STAT3与FOXM1表达水平,并采用全肺纤维化高分辨率CT(HRCT)评分评价IIP病情严重程度。分析三组受试者血清STAT3与FOXM1表达水平差异。对IIP组病人随访3个月,根据其生存情况分为预后良好组与预后不良组,分析预后不良与预后良好组IIP病人血清STAT3与FOXM1表达水平差异,并采用Spearman法分析IIP病人血清STAT3与FOXM1表达水平与全肺纤维化HRCT评分之间的关系。采用logistic回归分析IIP病人预后不良的影响因素,绘制受试者操作特征曲线(ROC曲线)评估血清STAT3与FOXM1表达水平对IIP病人预后不良的预测效能。结果IIP组、UIP组、对照组血清STAT3[(1.50±0.39)ng/L、(1.32±0.31)ng/L、(1.01±0.27)ng/L]、FOXM1[(34.56±5.64)ng/L、(22.69±4.11)ng/L、(15.51±3.94)ng/L]水平均依次降低(P<0.05)。IIP病人随访3个月共有41例病人死亡,预后不良发生率为13.76%(41/298);预后不良组IIP病人血清STAT3、FOXM1水平均高于预后良好组(P<0.05)。Spearman相关性分析表明,IIP病人血清STAT3、FOXM1水平均与全肺纤维化HRCT评分正相关(rs=0.65,rs=0.57;P<0.001)。另预后不良组年龄、Ⅱ型肺泡细胞表面抗原(KL-6)、白细胞计数、红细胞沉降率(ESR)、C反应蛋白(CRP)水平、全肺纤维化HRCT评分均高于预后良好组(P<0.05);第一秒用力呼气量(FEV1)、最大自主通气量(MVV)均低于预后良好组(P<0.05)。多因素logistic回归分析显示,年龄、KL-6、白细胞、ESR、CRP、STAT3、FOXM1水平、全肺纤维化HRCT评分均是导致IIP病人预后�Objective To investigate the expression levels of serum signal tranducers and activators of transcription 3(STAT3)and forkhead box M1(FOXM1)in patients with idiopathic interstitial pneumonia(IIP)and their relationship with severity and prognosis.Methods A total of 298 patients with IIP admitted to Sichuan Architectural Hospital from January 2017 to October 2022 were collected as IIP group,another 298 usual interstitial pneumonia(UIP)patients admitted to our hospital at the same period were collected as the UIP group,another 280 healthy individuals who underwent physical examination in our hospital were collected as the control group.The expression levels of serum STAT3 and FOXM1 were detected by enzyme linked immunosorbent assay(ELISA),the severity of IIP was evaluated using a high resolution CT(HRCT)score for total pulmonary fibrosis.The differences in serum STAT3 and FOXM1 expression levels among the three groups of subjects were analyzed.IIP patients were followed up for 3 months and were grouped into a good prognosis group and a poor prognosis group based on their survival.The differences in serum STAT3 and FOXM1 expression levels of IIP patients between the poor prognosis group and good prognosis groups were analyzed.Spearman method was applied to analyze the relationship between the expression levels of serum STAT3 and FOXM1 in patients with IIP and the HRCT score of total pulmonary fibrosis.Logistic regression was applied to analyze the influencing factors of poor prognosis in patients with IIP,and receiver operating characteristic curve(ROC curve)was drawn to evaluate the predictive efficacy of serum STAT3 and FOXM1 expression levels for poor prognosis in patients with IIP.Results The serum levels of STAT3[(1.50±0.39)ng/L,(1.32±0.31)ng/L,(1.01±0.27)ng/L]and FOXM1[(34.56±5.64)ng/L,(22.69±4.11)ng/L,(15.51±3.94)ng/L]in the IIP group,UIP group,and control group all decreased sequentially(P<0.05).A total of 41 patients died during a 3-month follow-up,with a poor prognosis rate of 13.76%(41/298),and the s

关 键 词：特发性间质性肺炎 信号转导及转录激活因子3 叉头框转录因子M1 病情程度 预后 相关性 

分 类 号：R563.13[医药卫生—呼吸系统]