血清Slit2蛋白水平与老年冠心病冠状动脉病变的相关性  

Correlation between serum Slit2 protein level and coronary artery lesions in elderly patients with coronary heart disease

作　　者：王科程 程德均 张鑫 杜怡颖 WANG Kecheng;CHENG Dejun;ZHANG Xin;DU Yiying(Department of Cardiovascular Medicine,3201 Hospital,Hanzhong,Shaanxi 723000,China)

机构地区：[1]三二〇一医院心血管内科,陕西汉中723000

出　　处：《安徽医药》2025年第1期147-151,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的检测老年冠心病病人血清中分泌型糖蛋白神经生长导向因子2(Slit2)蛋白表达水平,分析其与病人病情严重程度的相关性。方法回顾性收集2020年1月至2022年1月三二〇一医院收治的老年冠心病病人127例为研究组,另取该院同期体检健康者80例为对照组。采用冠脉狭窄程度(Gensini)分级将研究组分为轻度病变组52例、中度病变组43例、重度病变组32例。收集病人的一般临床资料,检测血清Slit2蛋白水平;采用Spearman等级相关分析血清Slit2蛋白与冠心病病人病情严重程度的相关性;logistic回归分析老年冠心病冠状动脉重度病变的影响因素;受试者操作特征曲线(ROC曲线)分析血清Slit2蛋白表达水平对冠心病冠状动脉重度病变的预测效能。结果轻度病变组、中度病变组、重度病变组病人总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平显著高于对照组,并且LDL-C水平随着病变程度的加重而增高(P<0.05)。研究组血清Slit2蛋白表达水平[(1.94±0.45)μg/L]显著低于对照组[(3.52±0.80)μg/L](P<0.05)。轻度[(2.47±0.55)μg/L]、中度[(1.85±0.41)μg/L]、重度病变组[(1.20±0.34)μg/L]病人血清Slit2蛋白表达水平依次降低(P<0.05)。Spearman分析显示,冠心病病人血清中Slit2蛋白表达水平与病情严重程度呈负相关(rs=−0.53,P<0.05)。多因素logistic回归分析显示,血清Slit2蛋白和LDL-C是老年冠心病冠状动脉重度病变的影响因素(P<0.05)。血清Slit2预测老年冠心病冠状动脉重度病变的ROC曲线下面积(AUC)为0.93,灵敏度为93.75%,特异度为88.37%,截断值为1.54μg/L,约登指数为0.82,LDL-C预测冠状动脉重度病变的AUC为0.89,灵敏度为87.50%,特异度为86.05%,截断值为3.48 mmol/L,约登指数为0.74,二者联合预测冠状动脉重度病变的AUC为0.96,灵敏度为96.87%,特异度为88.37%,约登指数为0.85。Slit2单独预测冠状动脉重度病变的AUC值与LDL-C单独预测AUC值�Objective To detect the expression level of Slit2 protein in the serum of elderly patients with coronary heart disease,and to analyze its correlation with the severity of the disease.Methods A total of 127 elderly patients with coronary heart disease admitted to 3201 Hospital from January 2020 to January 2022 were gathered as the research group,another 80 healthy people who underwent physical examination in our hospital were gathered as the control group.According to degree of coronary stenosis(Gensini)classification,the study group was divided into mild lesion group(52 cases),moderate lesion group(43 cases)and severe lesion group(32 cases).General clinical data of patients were collected and serum Slit2 protein levels were detected.Spearman rank correlation was used to analyze the correlation between serum Slit2 protein and the severity of coronary heart disease patients;Logistic regression analysis was used to analyze the influencing factors of severe coronary lesions in elderly patients with coronary heart disease;receiver operating characteristic curve(ROC curve)was used to analyze the predictive power of serum Slit2 protein expression level for severe coronary lesions in coronary heart disease.Results The levels of total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDLC)in the mild lesion group,moderate lesion group and severe lesion group were significantly higher than those in the control group,and the level of LDL-C increased with the severity of the lesion(P<0.05).The serum Slit2 protein expression level of the study group[(1.94±0.45)μg/L]was significantly lower than that of the control group[(3.52±0.80)μg/L](P<0.05).The serum Slit2 protein expression level of patients with mild[(2.47±0.55)μg/L],moderate[(1.85±0.41)μg/L]and severe disease group[(1.20±0.34)μg/L]was decreased successively(P<0.05).The Spearman analysis showed that the expression level of Slit2 protein in serum of patients with coronary heart disease was negatively correlated with the severity of the dise

关 键 词：冠心病 冠状动脉狭窄 老年人 分泌型糖蛋白神经生长导向因子2 相关性 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]