加味半夏泻心汤联合盐酸西替利嗪片递减法治疗慢性自发性荨麻疹(脾虚湿热证)疗效观察  

Clinical observation on the treatment of chronic spontaneous urticaria(spleen deficiency and damp heat syndrome)with Banxia Xiexin decoction and cetirizine hydrochloride tablets

作　　者：邹红 黄伟[2] 朱丹 刘丽云[1] ZOU Hong;HUANG Wei;ZHU Dan;LIU Liyun(Dermatological Department,Dazhou Integrated TCM and Western Medicine Hospital,Dazhou,Sichuan 635000,China;Gastroenterology Department,Dazhou Integrated TCM and Western Medicine Hospital,Dazhou,Sichuan 635000,China)

机构地区：[1]达州市中西医结合医院皮肤科,四川达州635000 [2]达州市中西医结合医院消化科,四川达州635000

出　　处：《安徽医药》2025年第1期169-173,共5页Anhui Medical and Pharmaceutical Journal

基　　金：四川省中医药管理局科学技术研究专项课题项目(2020LC0102)。

摘　　要：目的观察加味半夏泻心汤联合盐酸西替利嗪片递减法对慢性自发性荨麻疹(脾虚湿热证)的临床疗效。方法选取2021年1月至2022年6月达州市中西医结合医院确诊的慢性自发性荨麻疹(脾虚湿热证)70例,采用随机数字表分为治疗组与对照组,每组各35例。对照组给予西替利嗪片递减法治疗,治疗组在对照组基础上联用加味半夏泻心汤。两组总疗程为6周。在治疗第4周及第6周开始时,观察两组病人盐酸西替利嗪片使用情况,并于第6周治疗结束后,观察两组病例的临床疗效、西替利嗪片使用总量、荨麻疹活动度评分(UAS)及皮肤生活质量指数(DQLI)评分、血清总免疫球蛋白E(IgE)值、不良反应。并于治疗结束后8周统计复发情况。结果研究实际完成60例,两组各30例。治疗第4周及第6周开始时,治疗组盐酸西替利嗪片使用间隔时间明显高于对照组(治疗组西药减量速度高于对照组)(P<0.05)。6周后,治疗组治愈率为53.33%(16/30),对照组治愈率为20%(6/30);治疗组治愈率明显高于对照组(P<0.05);治疗组病人西替利嗪片使用总量明显低于对照组(P<0.05),治疗组UAS及DQLI评分比对照组低(P<0.05);不良反应两组无差异。疗程结束以后8周随访,复发率治疗组比对照组显著降低(P<0.05)。结论加味半夏泻心汤联合盐酸西替利嗪片递减法治疗慢性自发性荨麻疹(脾虚湿热证)临床疗效确切,可明显缩短病程,降低复发率。Objective To observe the clinical efficacy of Banxia Xiexin decoction combined with cetirizine hydrochloride tablets in the treatment of chronic spontaneous urticaria(spleen deficiency and damp heat syndrome).Methods A total of 70 cases of chronic spontaneous urticaria(spleen deficiency damp heat syndrome)diagnosed in the dermatological clinic of Dazhou Integrated Hospital of Traditional Chinese and Western Medicine from January 2021 to June 2022 were randomly divided into treatment group and control group using a random number table,with 35 cases in each group.The control group was treated with cetirizine tablets,while the treatment group was treated with Banxia Xiexin decoction combined with cetirizine hydrochloride tablets.The total course of treatment was 6 weeks.At the beginning of the 4th and 6th week of treatment,the use of cetirizine hydrochloride tablets in the two groups was observed,and at the end of the 6th week of treatment,the clinical efficacy,total use of cetirizine tablets,urticaria activity score(UAS)and skin quality of life index(DQLI)scores,serum total immunoglobulin E(IgE)values,and adverse reactions of the two groups were observed.The recurrence was measured 8 weeks after treatment.Results A total of 60 cases were completed in this study,each group had 30 cases.At the beginning of the 4th and 6th week of treatment,the interval between the use of cetirizine hydrochloride tablets in the treatment group was clearly higher than that in the control group(the reduction rate of western medicine in the treatment group was higher than that in the control group)(P<0.05).After 6 weeks,the cure rate of the treatment group was 53.33%(16/30),while the cure rate of the control group was 20%(6/30),the recovery rate in the treatment group was higher than that in the control group(P<0.05);UAS and DQLI scores in the treatment group were lower than those in the control group(P<0.05);There was no obviously difference in adverse reactions between the two groups.Follow up 8 weeks after the treatment,the recurrence

关 键 词：荨麻疹 半夏泻心汤 盐酸西替利嗪片 脾虚湿热证 临床疗效 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]