低分子量肝素钠联合拉贝洛尔治疗妊娠期高血压患者的效果  

Effects of low molecular weight Heparin sodium combined with Labetalol in treatment of patients with gestational hypertension

作　　者：党秀丽 DANG Xiuli(Department of Obstetrics and Gynecology of Yanling Hospital,Xuchang 461200 Henan,China)

机构地区：[1]鄢陵医院妇产科,河南许昌461200

出　　处：《中国民康医学》2024年第24期38-41,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察低分子量肝素钠联合拉贝洛尔治疗妊娠期高血压(PIH)患者的效果。方法:回顾性分析2019年5月至2023年7月该院收治的66例PIH患者的临床资料,按照治疗方法不同将其分为对照组和研究组各33例。两组均给予常规治疗,在此基础上,对照组给予拉贝洛尔治疗,研究组在对照组基础上联合低分子量肝素钠治疗。比较两组临床疗效,治疗前后血压(收缩压、舒张压)、血清学指标[胎盘生长因子(PLGF)、缺氧诱导因子-α(HIF-α)、同型半胱氨酸(Hcy)]水平,不良妊娠结局发生率,以及不良反应发生率。结果:研究组治疗总有效率为93.94%(31/33),高于对照组的75.76%(25/33),差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PLGF水平均高于治疗前,且研究组高于对照组,两组HIF-α、Hcy水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低分子量肝素钠联合拉贝洛尔治疗PIH患者可提高治疗总有效率,降低血压水平和不良妊娠结局发生率,改善血清学指标水平,效果优于单纯拉贝洛尔治疗。Objective:To observe effects of low molecular weight Heparin sodium combined with Labetalol in treatment of patients with pregnancy-induced hypertension(PIH).Methods:The clinical data of 66 patients with PIH admitted to the hospital from May 2019 to July 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,33 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Labetalol,while the study group was treated with low molecular weight Heparin sodium on the basis of that of the control group.The clinical efficacy,the blood pressure(systolic blood pressure,diastolic blood pressure),the serological indexes[placental growth factor(PLGF),hypoxia-inducible factor-α(HIF-α),homocysteine(Hcy)]levels before and after the treatment,the incidence of adverse pregnancy outcomes,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.94%(31/33),which was higher than 75.76%(25/33)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PLGF in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of HIF-αand Hcy in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incide

关 键 词：妊娠期高血压 低分子量肝素钠 拉贝洛尔 血压 不良妊娠结局 不良反应 

分 类 号：R714.246[医药卫生—妇产科学]