二甲双胍联合来曲唑治疗多囊卵巢综合征患者的效果  

Effects of Metformin combined with Letrozole in treatment of patients with polycystic ovary syndrome

作　　者：牛益璐 郭小伟 NIU Yilu;GUO Xiaowei(Department of Pharmacy of Luoyang Women and Child Health Hospital,Luoyang 471000 Henan,China)

机构地区：[1]洛阳市妇幼保健院药学部,河南洛阳471000

出　　处：《中国民康医学》2024年第24期45-48,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察二甲双胍联合来曲唑治疗多囊卵巢综合征患者的效果。方法:选取2021年4月至2023年3月该院收治的82例多囊卵巢综合征患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各41例。对照组给予来曲唑治疗,研究组在对照组基础上联合二甲双胍治疗。比较两组临床疗效,治疗前后性激素[卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平、糖代谢指标[空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)]水平、卵巢体积,以及不良反应发生率。结果:研究组治疗总有效率为95.12%(39/41),高于对照组的78.05%(32/41),差异有统计学意义(P<0.05);治疗后,两组FSH水平均高于治疗前,且研究组高于对照组,两组E_(2)、LH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组FINS水平均低于治疗前,且研究组低于对照组,两组FPG、HOMA-IR水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组左、右侧卵巢体积均小于治疗前,且研究组小于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:二甲双胍联合来曲唑治疗多囊卵巢综合征患者可提高治疗总有效率,改善性激素和糖代谢指标水平,以及缩小卵巢体积的效果优于单纯来曲唑治疗。Objective:To observe effects of Metformin combined with Letrozole in treatment of patients with polycystic ovary syndrome.Methods:A prospective study was conducted on 82 patients with polycystic ovary syndrome admitted to the hospital from April 2021 to March 2023.According to the random number table method,they were divided into control group and study group,41 cases in each group.The control group was treated with Letrozole,while the study group was treated with Metformin on the basis of that of the control group.The clinical efficacy,the levels of sex hormone[follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)]and glucose metabolism indexes[fasting insulin(FINS),fasting blood glucose(FPG),insulin resistance index(HOMA-IR)],the ovarian volume before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.12%(39/41),which was higher than 78.05%(32/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the FSH levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of E_(2) and LH in the two groups were lower than those before the treatment,and those in the observation group was lower than those in the control group;and the differences were statistically significant(P<0.05).The FINS levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of FPG and HOMA-IR in the two groups were lower than those before the treatment,and those in the study group was lower than those in the control group;and the differences were statistically significant(P<0.05).The left and right ovarian volumes of the two groups were smaller than those before the treatment,those in the study group were smaller than those in the control group,and the differences were statistically significant(P<0

关 键 词：二甲双胍 来曲唑 多囊卵巢综合征 性激素 卵巢体积 糖代谢 不良反应 

分 类 号：R711.75[医药卫生—妇产科学]